Peripheral and tissue eosinophilia can be a prominent feature of several unique rheumatologic and vascular diseases. These diseases span a wide range of clinical features, histologic findings, therapeutic approaches, and outcomes. Despite the rare nature of these entities--which makes large-scale studies challenging--knowledge has continued to grow regarding their epidemiology, pathophysiology, and management. This review compares and contrasts 5 rheumatologic and vascular conditions in which eosinophilia can be seen: eosinophilic granulomatosis with polyangiitis (Churg-Strauss), immunoglobulin G4-related disease, diffuse fasciitis with eosinophilia, eosinophilia-myalgia syndrome, and eosinophilic myositis.
Keywords: Diffuse fasciitis with eosinophilia; Eosinophilia-myalgia syndrome; Eosinophilic fasciitis; Eosinophilic granulomatosis with polyangiitis (Churg-Strauss); Eosinophilic myositis; Immunoglobulin G4-related disease.
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