Prolonged Complete Response in a Pediatric Patient With Primary Peripheral T-Cell Lymphoma of the Central Nervous System

Haneen Shalabi; Anne Angiolillo; Gilbert Vezina; James L Rubenstein; Stefania Pittaluga; Mark Raffeld; Leigh Marcus

doi:10.3109/08880018.2015.1074325

Prolonged Complete Response in a Pediatric Patient With Primary Peripheral T-Cell Lymphoma of the Central Nervous System

Pediatr Hematol Oncol. 2015;32(8):529-34. doi: 10.3109/08880018.2015.1074325. Epub 2015 Sep 18.

Authors

Haneen Shalabi¹, Anne Angiolillo¹, Gilbert Vezina², James L Rubenstein³, Stefania Pittaluga⁴, Mark Raffeld⁴, Leigh Marcus⁵

Affiliations

¹ a Division of Pediatric Hematology and Oncology, Center for Cancer and Blood Disorders , Children's National Medical Center , Washington, DC , USA.
² b Department of Radiology, Children's National Medical Center , Washington, DC , USA.
³ c Division of Hematology and Oncology , University of California, San Francisco , California , USA.
⁴ d Laboratory of Pathology , National Institutes of Health , Bethesda , Maryland , USA.
⁵ e Food and Drug Administration , Silver Spring , Maryland , USA.

Abstract

We describe a child with a 2-week history of progressive headaches, blurry vision, and intermittent vomiting. Magnetic resonance imaging (MRI) of the brain showed a deep left hemispheric lesion with extension into the corpus callosum. Histology and immunophenotyping of the lesion was consistent with peripheral T-cell lymphoma, not otherwise specified. Chemotherapy was initiated and a complete remission was achieved. This case illustrates that a chemotherapeutic regimen used in adults with central nervous system (CNS) lymphoma can achieve durable remissions in pediatric patients with peripheral T-cell lymphoma, not otherwise specified of the CNS.

Keywords: CNS tumors; NHL; therapy.

Publication types

Case Reports

MeSH terms

Brain Neoplasms / diagnostic imaging*
Brain Neoplasms / drug therapy*
Child
Corpus Callosum / diagnostic imaging*
Female
Humans
Lymphoma, T-Cell, Peripheral / diagnostic imaging*
Lymphoma, T-Cell, Peripheral / drug therapy*
Magnetic Resonance Imaging*
Radiography
Remission Induction

Abstract

Publication types

MeSH terms

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