Next generation sequencing based identification of disease-associated mutations in Swiss patients with retinal dystrophies

Sci Rep. 2016 Jun 29:6:28755. doi: 10.1038/srep28755.

Abstract

Inherited monogenic diseases of the retina and vitreous affect approximately 1 in 2000 individuals. They are characterized by tremendous genetic heterogeneity and clinical variability involving mutations in approximately 250 genes and more than 20 different clinical phenotypes. Clinical manifestations of retinal dystrophies (RDs) range from mild retinal dysfunctions to severe congenital forms of blindness. A detailed clinical diagnosis and the identification of causative mutations are crucial for genetic counseling of affected patients and their families, for understanding genotype-phenotype correlations and developing therapeutic approaches. Using whole exome sequencing (WES) we have established a reliable and efficient high-throughput analysis pipeline to identify disease-causing mutations. Our data indicate that this approach enables us to genetically diagnose approximately 64% of the patients (n = 58) with variant(s) in known disease-associated genes. We report 20 novel and 26 recurrent variants in genes associated with RDs. We also identified a novel phenotype for mutations in C2orf71 and provide functional evidence for exon skipping due to a splice-site variant identified in FLVCR1. In conclusion, WES can rapidly identify variants in various families affected with different forms of RDs. Our study also expands the clinical and allelic spectrum of genes associated with RDs in the Swiss population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Exome Sequencing
  • Eye Proteins / genetics*
  • Female
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Male
  • Membrane Transport Proteins / genetics*
  • Mutation*
  • Receptors, Virus / genetics*
  • Retinal Dystrophies / epidemiology
  • Retinal Dystrophies / genetics*
  • Switzerland / epidemiology

Substances

  • Eye Proteins
  • FLVCR1 protein, human
  • Membrane Transport Proteins
  • PCARE protein, human
  • Receptors, Virus