Steroid-induced glaucoma in the pediatric population

J AAPOS. 2017 Feb;21(1):1-6. doi: 10.1016/j.jaapos.2016.09.026. Epub 2017 Jan 10.

Abstract

Steroid medications may cause elevation of intraocular pressure, sometimes with permanent damage to the optic nerve. These therapies, via various routes of administration, are commonly prescribed for children, but the potential sequelae of elevated intraocular pressure and glaucomatous optic nerve damage can be even more severe and devastating in children than in adults. This review discusses the pathophysiology and potential risk factors, including the impact of intraocular pressure elevation via the different common routes of administration of steroids, clinical evaluation, and management of steroid response and steroid-induced glaucoma in children.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Glaucoma / chemically induced*
  • Glaucoma / physiopathology
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / adverse effects*
  • Humans
  • Infant
  • Infant, Newborn
  • Intraocular Pressure / drug effects*
  • Intraocular Pressure / physiology
  • Risk Factors
  • Trabecular Meshwork / drug effects
  • Trabecular Meshwork / physiopathology
  • Visual Acuity / drug effects
  • Visual Fields / drug effects

Substances

  • Glucocorticoids