Abstract
Foscarnet sodium is an antiviral drug for the treatment of CMV retinitis, currently in the form of twice-weekly intravitreal injection. Here we developed foscarnet calcium microcrystals as the drug depot, and using the rabbit model we demonstrated that the injected microcrystals maintained a therapeutically relevant drug concentration in the vitreous for more than 3 months.
MeSH terms
-
Animals
-
Antiviral Agents / administration & dosage*
-
Antiviral Agents / chemistry
-
Antiviral Agents / pharmacokinetics*
-
Crystallization
-
Cytomegalovirus Retinitis / metabolism*
-
Foscarnet / administration & dosage*
-
Foscarnet / chemistry
-
Foscarnet / pharmacokinetics*
-
Intravitreal Injections
-
Models, Animal
-
Particle Size
-
Rabbits
Substances
-
Antiviral Agents
-
Foscarnet