Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

Cell Metab. 2017 Jul 5;26(1):17-23. doi: 10.1016/j.cmet.2017.05.014.

Abstract

Elevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting β cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in β cells in normoglycemia and in diabetes.

Keywords: diabetes; glycogen; insulin; pancreatic β cell.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Glycogen / metabolism*
  • Glycogen Storage Disease / blood
  • Glycogen Storage Disease / complications
  • Glycogen Storage Disease / metabolism*
  • Glycogen Storage Disease / physiopathology
  • Humans
  • Insulin-Secreting Cells / metabolism*
  • Insulin-Secreting Cells / pathology
  • Signal Transduction

Substances

  • Blood Glucose
  • Glycogen