An open-label trial of JAK 1/2 blockade in progressive IFIH1-associated neuroinflammation

Neurology. 2018 Feb 6;90(6):289-291. doi: 10.1212/WNL.0000000000004921. Epub 2018 Jan 10.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Cytokines / cerebrospinal fluid
  • Disease Progression
  • Enzyme Inhibitors / therapeutic use*
  • Humans
  • Inflammation / cerebrospinal fluid
  • Inflammation / drug therapy*
  • Inflammation / genetics
  • Interferon-Induced Helicase, IFIH1 / genetics*
  • Janus Kinases / metabolism*
  • Longitudinal Studies
  • Male
  • Mutation / genetics
  • Nitriles
  • Pyrazoles / therapeutic use*
  • Pyrimidines
  • Signal Transduction / drug effects

Substances

  • Cytokines
  • Enzyme Inhibitors
  • Nitriles
  • Pyrazoles
  • Pyrimidines
  • ruxolitinib
  • Janus Kinases
  • IFIH1 protein, human
  • Interferon-Induced Helicase, IFIH1