Genetic variation in VAC14 is associated with bacteremia secondary to diverse pathogens in African children

James J Gilchrist; Alexander J Mentzer; Anna Rautanen; Matti Pirinen; Salim Mwarumba; Patricia Njuguna; Neema Mturi; Wellcome Trust Case-Control Consortium 2; Kenyan Bacteraemia Study Group; Thomas N Williams; J Anthony G Scott; Adrian V S Hill

doi:10.1073/pnas.1802071115

Genetic variation in VAC14 is associated with bacteremia secondary to diverse pathogens in African children

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3601-E3603. doi: 10.1073/pnas.1802071115. Epub 2018 Mar 27.

Authors

Collaborators

Adrian V S Hill, Thomas N Williams, J Anthony G Scott, Stephen J Chapman, Anna Rautanen, Tara C Mills, Kirk Rockett, Anne W Ndungu, Vivek Naranbhai, Alex W Macharia, Sophie Uyoga, Carolyne Ndila, Neema Mturi, Patricia Njuguna, Shebe Mohammed, James A Berkley, Isaiah Mwangi, Salim Mwarumba, Barnes S Kitsao, Brett S Lowe, Susan C Morpeth, Iqbal Khandwalla, Alex W Macharia, Sophie Uyoga, Herbert Opi, Carolyne Ndila, Emily Nyatichi, Prophet Ingosi, Barnes Kitsao, Clement Lewa, Johnstone Makale, Adan Mohamed, Kenneth Magua, Mary Njoroge, Gideon Nyutu, Ruth Mwarabu, Metrine Tendwa, Thomas N Williams, Ismail Ahmed, Samuel Akech, Alexander Balo Makazi, Mohammed Bakari Hajj, Andrew Brent, Charles Chesaro, Hiza Dayo, Richard Idro, Patrick Kosgei, Kathryn Maitland, Kevin Marsh, Laura Mwalekwa, Shalton Mwaringa, Charles Newton, Mwanajuma Ngama, Allan Pamba, Norbert Peshu, Anna Seale, Alison Talbert, Thomas N Williams, Peter Donnelly, Ines Barroso, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Panos Deloukas, Audrey Duncanson, Janusz Jankowski, Hugh S Markus, Christopher G Mathew, Colin Na Palmer, Robert Plomin, Anna Rautanen, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas W Wood, Chris C A Spencer, Gavin Band, Céline Bellenguez, Colin Freeman, Garrett Hellenthal, Eleni Giannoulatou, Matti Pirinen, Richard Pearson, Amy Strange, Zhan Su, Damjan Vukcevic, Peter Donnelly, Cordelia Langford, Sarah E Hunt, Sarah Edkins, Rhian Gwilliam, Hannah Blackburn, Suzannah J Bumpstead, Serge Dronov, Matthew Gillman, Emma Gray, Naomi Hammond, Alagurevathi Jayakumar, Owen T McCann, Jennifer Liddle, Simon C Potter, Radhi Ravindrarajah, Michelle Ricketts, Matthew Waller, Paul Weston, Sara Widaa, Pamela Whittaker, Ines Barroso, Panos Deloukas, Christopher G Mathew, Jenefer M Blackwell, Matthew A Brown, Aiden Corvin, Chris C A Spencer

Affiliations

¹ Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom; james.gilchrist@well.ox.ac.uk.
² Department of Paediatrics, University of Oxford, Oxford OX3 9DU, United Kingdom.
³ Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.
⁴ Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland.
⁵ Centre for Geographic Medicine Research, Kenya Medical Research Institute-Wellcome Trust Clinical Research Programme, Kilifi 80108, Kenya.
⁶ Department of Medicine, Imperial College London, London W2 1PG, United Kingdom.
⁷ Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, United Kingdom.
⁸ The Jenner Institute, University of Oxford, Oxford, OX3 7DQ, United Kingdom.

No abstract available

Publication types

Letter
Comment

MeSH terms

Bacteremia*
Child
Genetic Variation*
Humans
Intracellular Signaling Peptides and Proteins
Membrane Proteins / genetics

Substances

Intracellular Signaling Peptides and Proteins
Membrane Proteins
VAC14 protein, human

Grants and funding

Wellcome Trust/United Kingdom