The mainstay of open-angle glaucoma surgery involves subconjunctival drainage of aqueous fluid. Insertion of the XEN Gel Stent leads to formation of a subconjunctival bleb to assist in the drainage of aqueous fluid and offers the advantage of ease and speed of insertion with conjunctival sparing over traditional surgical techniques. This is the first case of XEN Gel Stent-related endophthalmitis associated with extrusion and breakage of the stent, a previously undocumented complication of this relatively new surgery.