Serpiginous-Like Choroiditis (SLC) - Morphology and Treatment Outcomes

Ocul Immunol Inflamm. 2020 May 18;28(4):667-675. doi: 10.1080/09273948.2019.1611878. Epub 2019 Aug 12.

Abstract

Purpose: To study morphology and treatment outcomes in serpiginous-like choroiditis (SLC).

Methods: A retrospective chart review of SLC cases with ≥1-year follow-up. SLC lesions with elongated borders, thin body named dendritic (D-SLC), large lesions still with elongated borders named advanced dendritic (AD-SLC), and lesions with rounded borders, thick body called placoid (P-SLC). History, investigations, treatment response, and relapses were studied.

Results: Thirty-three eyes [D-SLC (n = 14), AD-SLC (n = 13), P-SLC (n = 6)] of 24 patients were studied. Resolution on Fundus autofluorescence achieved at 8.6 months (Range: 4-12 months). 0/16 eyes treated with anti-tubercular therapy (ATT) and 4/11 eyes treated without ATT had at least one recurrence in (D-SLC + AD-SLC) group (p = .019). Mean best corrected visual acuity at final follow-up was 20/20, 20/25, and 20/60 in D-SLC, AD-SLC, and in P-SLC, respectively.

Conclusion: P-SLC has poor visual prognosis compared to AD-SLC and D-SLC. ATT may prevent recurrences in D-SLC and AD-SLC.

Keywords: Dendritic; placoid; serpiginous-like choroiditis; tubercular; viral.

Publication types

  • Comparative Study
  • Observational Study

MeSH terms

  • Adult
  • Choroid / pathology*
  • Choroiditis / diagnosis*
  • Choroiditis / drug therapy
  • Female
  • Fluorescein Angiography / methods*
  • Follow-Up Studies
  • Fundus Oculi
  • Glucocorticoids / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Retinal Vessels / pathology*
  • Retrospective Studies
  • Time Factors
  • Visual Acuity*

Substances

  • Glucocorticoids