A Long-Term Follow-up of Retinal Vasculitis - Do They Develop Systemic Disease?

Ocul Immunol Inflamm. 2020 Nov 16;28(8):1181-1186. doi: 10.1080/09273948.2019.1697455. Epub 2020 Jan 6.

Abstract

Purpose: To study systemic association and relapses in a long-term follow-up of primary retinal vasculitis (PRV) and possible tubercular vasculitis (PTV) cases. Method: Retrospective, descriptive chart review of patients diagnosed as PRV and PTV with ≥1-year follow-up. Clinical presentation, systemic association, morphology of vasculitis, relapses, and treatment were noted. Results: 123 eyes of 76 patients were studied. Occlusive (n = 97), exudative (n = 16), combined (n = 10) and focal (n = 7) vasculitis were seen. Vitreous hemorrhage at presentation was noted in 27% eyes (n = 33). Four patients (3.25%) developed systemic disease during follow-up (2 psoriasis, 1 Systemic Lupus Erythematosus, 1 ulcerative colitis). Mean number of cases with relapses were 45 (59.21%). Number of cases with relapses in PRV and PTV were 20 (66.66%) and 16 (66.66%), respectively. (p = 1) Conclusion: Systemic disease attributed to vasculitis can rarely develop during follow up of PRV and PTV patients. Relapses remain almost same in PTV and PRV.

Keywords: Retinal vasculitis; long-term follow-up; recurrences; systemic disease; tuberculosis.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antitubercular Agents / therapeutic use
  • Azathioprine / therapeutic use
  • Colitis, Ulcerative / diagnosis*
  • Colitis, Ulcerative / drug therapy
  • Colitis, Ulcerative / physiopathology
  • Cyclosporine / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Glucocorticoids / therapeutic use
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Lupus Erythematosus, Systemic / diagnosis*
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / physiopathology
  • Male
  • Methotrexate / therapeutic use
  • Middle Aged
  • Psoriasis / diagnosis*
  • Psoriasis / drug therapy
  • Psoriasis / physiopathology
  • Recurrence
  • Retinal Vasculitis / diagnosis*
  • Retinal Vasculitis / drug therapy
  • Retinal Vasculitis / physiopathology
  • Retrospective Studies
  • Tuberculin Test
  • Tuberculosis, Ocular / diagnosis
  • Tuberculosis, Ocular / drug therapy
  • Tuberculosis, Ocular / physiopathology
  • Visual Acuity
  • Vitreous Hemorrhage / diagnosis
  • Vitreous Hemorrhage / drug therapy

Substances

  • Antitubercular Agents
  • Glucocorticoids
  • Immunosuppressive Agents
  • Cyclosporine
  • Azathioprine
  • Methotrexate