Lack of Relationship between Central Corneal Thickness and Papilloedema in Idiopathic Intracranial Hypertension

Jason H Peragallo; Caroline Vasseneix; Michael Dattilo; Nancy J Newman; Valérie Biousse; Beau B Bruce

doi:10.1080/01658107.2019.1588337

Lack of Relationship between Central Corneal Thickness and Papilloedema in Idiopathic Intracranial Hypertension

Neuroophthalmology. 2019 Mar 14;43(6):371-374. doi: 10.1080/01658107.2019.1588337. eCollection 2019 Dec.

Authors

Jason H Peragallo^{1

2}, Caroline Vasseneix¹, Michael Dattilo¹, Nancy J Newman^{1

3

4}, Valérie Biousse^{1

3}, Beau B Bruce^{1

3

5}

Affiliations

¹ Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
² Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
³ Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
⁴ Department of Neurological Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
⁵ Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Abstract

Translaminar pressure gradient abnormalities have been implicated in the pathogenesis and progression of glaucoma. A "reversed" translaminar pressure gradient may be related to papilloedema severity in idiopathic intracranial hypertension. Central corneal thickness is related to intraocular pressure measurements and, by extension, to translaminar pressure gradients. We evaluated if central corneal thickness could be a marker of worse papilloedema due to altered translaminar pressure gradients in patients with idiopathic intracranial hypertension. We found that central corneal thickness was not related to the severity of papilloedema in idiopathic intracranial hypertension.

Keywords: Central corneal thickness; glaucoma; idiopathic intracranial hypertension; translaminar pressure gradient.

Grants and funding

This work was supported in part by an unrestricted departmental grant (Department of Ophthalmology) from Research to Prevent Blindness, Inc., New York; and by NIH/National Eye Institute [P30-EY06360].