Calcifying pseudoneoplasm of the neuroaxis presenting with refractory seizures: Case report and literature review

J Clin Neurosci. 2020 Aug:78:439-443. doi: 10.1016/j.jocn.2020.05.001. Epub 2020 May 6.

Abstract

Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare benign lesions that can arise anywhere within the central nervous system. The etiology of these lesions remains unknown and diagnosis is made on pathohistological analysis. We present the case of a 35-year-old male patient with a history of epilepsy since childhood who was evaluated for refractory seizures. MRI revealed a small lesion in the left-posterior temporal lobe suspected to be a cavernoma. A gross total resection of the lesion was achieved via a left temporal craniotomy and pathological analysis revealed CAPNON. At 6 months follow-up, the patient remained neurologically intact and his seizures had ceased.

Keywords: CAPNON; Calcifying pseudoneoplasm of the neuroaxis; Cavernoma; Epilepsy; Seizures.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Calcinosis / complications
  • Calcinosis / diagnostic imaging
  • Calcinosis / pathology*
  • Central Nervous System / pathology*
  • Cephalometry
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Seizures / etiology*
  • Temporal Lobe / pathology
  • Temporal Lobe / surgery
  • Treatment Outcome