Fourty-one patients, referred to the Department of Radiology, Chiba University Hospital from 1975 through July, 1987, have been analyzed to determine their prognostic factors. These patients showed a less favorable prognosis (2 and 5 year actuarial survival, 30% and 19% respectively) compared with the younger patients. The histological grade by WF and their clinical stage reflected the prognosis well. Although the achievement of complete remission seemed to affect prognosis favorably, aggressive regimens with chemotherapy and/or radiotherapy often caused their deaths. In senile patients with NHL, it is a prerequisite to consider the effects on the patient of curative therapy more carefully, especially when Adriamycin is used.