Markers associated with malignant transformation of oral lichen planus: A review article

Narges Ghazi; Maryam Khorasanchi

doi:10.1016/j.archoralbio.2021.105158

Markers associated with malignant transformation of oral lichen planus: A review article

Arch Oral Biol. 2021 Jul:127:105158. doi: 10.1016/j.archoralbio.2021.105158. Epub 2021 May 15.

Authors

Narges Ghazi¹, Maryam Khorasanchi²

Affiliations

¹ Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: ghazin@mums.ac.ir.
² Student Research Committee, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: KhorasanchiM941@mums.ac.ir.

PMID: 34022545
DOI: 10.1016/j.archoralbio.2021.105158

Abstract

Oral lichen planus (OLP) is one of the autoimmune diseases associated with chronic inflammation that involves several complications including the potential for malignant transformation into oral squamous cell carcinoma. Pathogenesis of OLP are yet to be fully comprehended however, it has been demonstrated that the epithelial cells in OLP lesions are affected by cytotoxic T lymphocytes leading to immunological reactions. Various factors are reported to act as diagnostic markers for predicting and monitoring the cancerous progression. Hence, in this review, we summarize and present the latest studies regarding the predictive markers associated with malignant potential of OLP.

Keywords: Biomarker; Inflammation; Malignant potential; Malignant transformation; Oral lichen planus; Premalignant oral lesion.

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell*
Cell Transformation, Neoplastic
Head and Neck Neoplasms*
Humans
Lichen Planus, Oral*
Mouth Neoplasms*