The Immediate Onset of Isolated and Unilateral Abducens Nerve Palsy Associated with COVID-19 Infection: A Case Report and Literature Review

Intern Med. 2022;61(11):1761-1765. doi: 10.2169/internalmedicine.9308-22. Epub 2022 Jun 1.

Abstract

Cranial nerve palsy associated with coronavirus disease 2019 (COVID-19) is rare. We herein report the first Asian case of the immediate onset of isolated and unilateral abducens nerve palsy (ANP) accompanied with COVID-19 infection. A 25-year-old man developed diplopia one day after the COVID-19 symptom onset. Neurological examination revealed limitation of left eye abduction without ataxia and hyporeflexia. Negative anti-ganglioside antibody results and mild albuminocytological dissociation were noted. The patient was diagnosed with left ANP accompanied by COVID-19 infection. The ANP spontaneously recovered without treatment. ANP can develop during the early phase of COVID-19 infection and adversely affect patients' quality of life.

Keywords: COVID-19; Miller Fisher syndrome; SARS-CoV-2; abducens nerve palsy; anti-GQ1-b antibody; neurological complication.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Abducens Nerve
  • Abducens Nerve Diseases* / etiology
  • Adult
  • COVID-19* / complications
  • Humans
  • Male
  • Quality of Life