Progress in the pharmacotherapy of uveitis: the art of personalized care

Expert Opin Pharmacother. 2022 Aug;23(12):1445-1455. doi: 10.1080/14656566.2022.2104637. Epub 2022 Aug 18.

Abstract

Introduction: Uveitis is a heterogeneous group of inflammatory intraocular disorders that can lead to blindness, but prompt diagnosis and management can improve visual outcomes and reduce treatment burden.

Areas covered: In this review, the authors provide an overview of commonly used treatments for the management of noninfectious uveitis.

Expert opinion: Initially, the treatment of noninfectious uveitis was limited to corticosteroids, which have a broad range of adverse ocular and systemic effects. Now new delivery and therapeutic options, such as biological response modulators, represent novel yet exciting additions to this armory and have the potential to alter the course of treatment as well as prognostic outcomes for uveitis patients. Further research is needed to evaluate the efficacy of this novel class of immunomodulators in uveitis therapy.

Keywords: Alkylating agents antimetabolites; biologic response modulators; corticosteroids; pharmacotherapy; uveitis.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones
  • Humans
  • Immunologic Factors
  • Immunotherapy
  • Uveitis*

Substances

  • Adrenal Cortex Hormones
  • Immunologic Factors