Dab2 (Disabled-2), an adaptor protein, regulates self-renewal of hair follicle stem cells

Commun Biol. 2024 May 3;7(1):525. doi: 10.1038/s42003-024-06047-2.

Abstract

Disabled 2 (Dab2), an adaptor protein, is up regulated in the hair follicle stem cells (HFSCs); however, its role in any tissue stem cells has not been studied. In the present study, we have reported that Dab2 conditional knockout (Dab2-cKO) mice exhibited a delay in the HF cycle due to perturbed activation of HFSCs. Further, Dab2-cKO mice showed a reduction in the number of HFSCs and reduced colony forming ability of HFSCs. Dab2-cKO mice showed extended quiescence of HFSCs concomitant with an increased expression of Nfatc1. Dab2-cKO mice showed a decreased expression of anti-aging genes such as Col17a1, decorin, Sirt2 and Sirt7. Dab2-cKO mice did not show full hair coat recovery in aged mice thereby suggesting an accelerated aging process. Overall, we unveil for the first time, the role of Dab2 that regulate activation and self-renewal of HFSCs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing* / genetics
  • Adaptor Proteins, Signal Transducing* / metabolism
  • Animals
  • Apoptosis Regulatory Proteins* / genetics
  • Apoptosis Regulatory Proteins* / metabolism
  • Cell Proliferation
  • Cell Self Renewal / genetics
  • Hair Follicle* / cytology
  • Hair Follicle* / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout*
  • Stem Cells* / metabolism

Substances

  • Dab2 protein, mouse
  • Adaptor Proteins, Signal Transducing
  • Apoptosis Regulatory Proteins