Report from the World Health Organization's immunization and vaccines-related implementation research advisory committee (IVIR-AC) meeting, virtual gathering, 26 February-1 March 2024

Philipp Lambach; Sheetal Silal; Alyssa N Sbarra; Mitsuki Koh; Rakesh Aggarwal; Habib Hasan Farooqui; Stefan Flasche; Alexandra B Hogan; Sun-Young Kim; Kathy Leung; William J Moss; Patrick K Munywoki; Allison Portnoy; Meru Sheel; Xuan-Yi Wang

doi:10.1016/j.vaccine.2024.04.057

Report from the World Health Organization's immunization and vaccines-related implementation research advisory committee (IVIR-AC) meeting, virtual gathering, 26 February-1 March 2024

Vaccine. 2024 May 3:S0264-410X(24)00494-8. doi: 10.1016/j.vaccine.2024.04.057. Online ahead of print.

Authors

Affiliations

¹ Immunizations, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland.
² Modelling and Simulation Hub, Africa, University of Cape Town, Cape Town, South Africa; Centre for Global Health, Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom.
³ Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: asbarra1@jhu.edu.
⁴ Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India.
⁵ College of Medicine, QU Health, Qatar University, Qatar.
⁶ Centre for Global Health, Charite, Berlin, Germany.
⁷ School of Population Health, University of New South Wales, Sydney, Australia.
⁸ Seoul National University, Seoul, South Korea.
⁹ School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region.
¹⁰ Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
¹¹ Kenya Medical Research Institute, Centre for Global Health Research, Nairobi, Kenya.
¹² Department of Global Health, Boston University School of Public Health, Boston, United States; Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, United States.
¹³ School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
¹⁴ Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.

PMID: 38704250
DOI: 10.1016/j.vaccine.2024.04.057

Abstract

The Immunization and Vaccine-related Implementation Research Advisory Committee (IVIR-AC) is the World Health Organization's key standing advisory body to conduct an independent review of research, particularly of transmission and economic modeling analyses that estimate the impact and value of vaccines. From 26th February-1st March 2024, at its first of two semi-annual meetings, IVIR-AC provided feedback and recommendations across four sessions; this report summarizes the proceedings and recommendations from that meeting. Session topics included modeling of the impact and cost-effectiveness of the R21/Matrix-M malaria vaccine, meta-analysis of economic evaluations of vaccines, a global analysis estimating the impact of vaccination over the last 50 years, and modeling the impact of different RTS,S malaria vaccine dose schedules in seasonal settings.

Keywords: EPI; Economic evaluation; IVIR-AC; Malaria; Meta-analysis.