AMRViz enables seamless genomics analysis and visualization of antimicrobial resistance

BMC Bioinformatics. 2024 May 16;25(1):193. doi: 10.1186/s12859-024-05792-9.

Abstract

We have developed AMRViz, a toolkit for analyzing, visualizing, and managing bacterial genomics samples. The toolkit is bundled with the current best practice analysis pipeline allowing researchers to perform comprehensive analysis of a collection of samples directly from raw sequencing data with a single command line. The analysis results in a report showing the genome structure, genome annotations, antibiotic resistance and virulence profile for each sample. The pan-genome of all samples of the collection is analyzed to identify core- and accessory-genes. Phylogenies of the whole genome as well as all gene clusters are also generated. The toolkit provides a web-based visualization dashboard allowing researchers to interactively examine various aspects of the analysis results. Availability: AMRViz is implemented in Python and NodeJS, and is publicly available under open source MIT license at https://github.com/amromics/amrviz .

Keywords: Antimicrobial resistance; Microbial genomics; Visualization.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects
  • Bacteria / genetics
  • Drug Resistance, Bacterial / genetics
  • Genome, Bacterial*
  • Genomics* / methods
  • Phylogeny
  • Software*