The existence of renewed peripheral sub-retinal vascularization has been known for some time, but it has not attracted the attention that it merits. It possesses similar features to that of renewed sub-retinal vascularization of the posterior pole, and the consequences of this condition are well known. Two clinical cases are reported in which clinical and angiographic investigations demonstrated this type of alteration. Histological examinations showed its continuity with the choriocapillary. It is possible, though still not conclusively demonstrated, that renewed peripheral sub-retinal vascularization plays an important role in peripheral retinal diseases such as serohemorrhagic detachments of the peripheral retinal degenerations.