Gonio-photocoagulation is a name applied to direct laser therapy to neovascular vessels in the anterior chamber angle in progressive anterior segment neovascularization. The technique is useful not in altering the stimulus to anterior segment neovascularization, but in immediately altering the product of the stimulus, the new vessels in the angle. The goal is to halt immediately progression toward angle closure and severe neovascular glaucoma. A recommended protocol is presented for incorporation of this technique into a prophylactic regimen for neovascular glaucoma in conjunction with retinal therapy to alter the stimulus.