A non-antimicrobial tetracycline inhibits gingival matrix metalloproteinases and bone loss in Porphyromonas gingivalis-induced periodontitis in rats

Ann N Y Acad Sci. 1994 Sep 6:732:96-111. doi: 10.1111/j.1749-6632.1994.tb24728.x.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bacteroidaceae Infections / drug therapy
  • Bacteroidaceae Infections / physiopathology*
  • Bone Resorption / prevention & control*
  • Collagenases / metabolism
  • Doxycycline / therapeutic use*
  • Enzyme Activation
  • Gelatinases / metabolism
  • Gingiva / enzymology*
  • Male
  • Matrix Metalloproteinase Inhibitors
  • Metalloendopeptidases / antagonists & inhibitors
  • Metalloendopeptidases / metabolism*
  • Pancreatic Elastase / metabolism
  • Periodontitis / drug therapy
  • Periodontitis / physiopathology*
  • Porphyromonas gingivalis*
  • Rats
  • Rats, Sprague-Dawley
  • Tetracycline / therapeutic use*

Substances

  • Matrix Metalloproteinase Inhibitors
  • 4-des-dimethylaminotetracycline
  • Pancreatic Elastase
  • Collagenases
  • Gelatinases
  • Metalloendopeptidases
  • Tetracycline
  • Doxycycline