Benign adenoma of iris pigment epithelium is a rare neoformation characterized by a multinodular, dark brown to dark black, relatively stationary lesion, especially localized in the peripheral iris. We report a case of iris pigment epithelium adenoma with no evidence of change during the 6-year follow-up. Iris fluorescein angiography showed a mild staining of the lesion without evidence of abnormal vessels. The importance of fluorescence iridography in the differential diagnosis of iris-pigmented lesions is discussed.