Abstract
A 36-year-old patient with acquired immunodeficiency syndrome sought care because of an upper eyelid lesion that dramatically increased in size. The histopathologic examination revealed a high-grade diffuse large cell non-Hodgkin lymphoma in continuity with a Kaposi sarcoma. In situ hybridization revealed Epstein-Barr virus in the large cell lymphoma and Kaposi sarcoma-associated herpesvirus in the Kaposi sarcoma lesion. This collision tumor is an unusual presentation of 2 malignant neoplasms in a patient with acquired immunodeficiency syndrome, with in situ hybridization evidence of Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus in the lesion.
MeSH terms
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Adult
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Eye Infections, Viral / etiology
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Eye Infections, Viral / pathology
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Eyelid Neoplasms / pathology
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Eyelid Neoplasms / virology*
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Herpesviridae Infections / etiology*
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Herpesviridae Infections / pathology
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Herpesvirus 4, Human / genetics
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Herpesvirus 4, Human / isolation & purification
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Herpesvirus 8, Human / genetics
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Herpesvirus 8, Human / isolation & purification
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Humans
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In Situ Hybridization
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Lymphoma, AIDS-Related / pathology
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Lymphoma, AIDS-Related / virology*
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Lymphoma, Large-Cell, Immunoblastic / pathology
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Lymphoma, Large-Cell, Immunoblastic / virology*
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Male
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RNA, Messenger / analysis
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RNA, Viral / analysis
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Sarcoma, Kaposi / pathology
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Sarcoma, Kaposi / virology*
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Tumor Virus Infections / etiology*
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Tumor Virus Infections / pathology
Substances
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RNA, Messenger
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RNA, Viral