Orbital granulocytic sarcoma in an elderly patient

Am J Ophthalmol. 1997 Jun;123(6):854-6. doi: 10.1016/s0002-9394(14)71146-8.

Abstract

Purpose: To report a 71-year-old woman with acute myelogenous leukemia in remission who developed orbital granulocytic sarcoma.

Methods: The patient was referred for acute proptosis and decreased vision of the right eye. Computed tomography of the orbits demonstrated a right extraconal mass compressing the optic nerve. A right lateral orbitotomy was performed, and a portion of the mass was excised for diagnostic purposes and orbital decompression.

Results: Histopathologic and immunohistochemical evaluation disclosed orbital granulocytic sarcoma. With chemotherapy and radiation, vision remained stable and right proptosis resolved.

Conclusions: Orbital granulocytic sarcoma is usually diagnosed in children with a history of acute myelogenous leukemia. This case demonstrated that this entity may also occur rarely in older patients with a history of acute myelogenous leukemia.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Exophthalmos / pathology
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Leukemia, Myeloid / diagnostic imaging
  • Leukemia, Myeloid / pathology*
  • Leukemia, Myeloid / therapy
  • Mitoxantrone / therapeutic use
  • Orbital Neoplasms / diagnostic imaging
  • Orbital Neoplasms / pathology*
  • Orbital Neoplasms / therapy
  • Radiotherapy, Adjuvant
  • Tomography, X-Ray Computed
  • Vincristine / therapeutic use
  • Visual Acuity

Substances

  • Vincristine
  • Mitoxantrone