Horner's syndrome as a complication of lumbar epidural anesthesia is a relatively benign and transient condition that usually does not warrant further extensive investigation. Its occurrence is unpredictable, although more frequently associated with epidural anesthesia performed for obstetric conditions. It may indicate high sympathetic blockade, and those patients should be monitored closely for autonomic complications. We report two new cases of iatrogenic Horner's syndrome from lumbar epidural anesthesia.