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DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME, Ambati J. Tarallo V, et al. Among authors: nunez g. Cell. 2012 May 11;149(4):847-59. doi: 10.1016/j.cell.2012.03.036. Epub 2012 Apr 26. Cell. 2012. PMID: 22541070 Free PMC article.
Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.
Gelfand BD, Wright CB, Kim Y, Yasuma T, Yasuma R, Li S, Fowler BJ, Bastos-Carvalho A, Kerur N, Uittenbogaard A, Han YS, Lou D, Kleinman ME, McDonald WH, Núñez G, Georgel P, Dunaief JL, Ambati J. Gelfand BD, et al. Among authors: nunez g. Cell Rep. 2015 Jun 23;11(11):1686-93. doi: 10.1016/j.celrep.2015.05.023. Epub 2015 Jun 11. Cell Rep. 2015. PMID: 26074074 Free PMC article.
IL-18 is not therapeutic for neovascular age-related macular degeneration.
Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, Núñez G, Ambati BK, Hinton DR, Ambati J. Hirano Y, et al. Among authors: nunez g. Nat Med. 2014 Dec;20(12):1372-5. doi: 10.1038/nm.3671. Nat Med. 2014. PMID: 25473914 Free PMC article. No abstract available.
RNase L activates the NLRP3 inflammasome during viral infections.
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Núñez G, Silverman RH. Chakrabarti A, et al. Among authors: nunez g. Cell Host Microbe. 2015 Apr 8;17(4):466-77. doi: 10.1016/j.chom.2015.02.010. Epub 2015 Mar 26. Cell Host Microbe. 2015. PMID: 25816776 Free PMC article.
Mechanism and Regulation of NLRP3 Inflammasome Activation.
He Y, Hara H, Núñez G. He Y, et al. Among authors: nunez g. Trends Biochem Sci. 2016 Dec;41(12):1012-1021. doi: 10.1016/j.tibs.2016.09.002. Epub 2016 Sep 23. Trends Biochem Sci. 2016. PMID: 27669650 Free PMC article. Review.
592 results