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Viral serpin therapeutics from concept to clinic.
Chen H, Zheng D, Davids J, Bartee MY, Dai E, Liu L, Petrov L, Macaulay C, Thoburn R, Sobel E, Moyer R, McFadden G, Lucas A. Chen H, et al. Methods Enzymol. 2011;499:301-29. doi: 10.1016/B978-0-12-386471-0.00015-8. Methods Enzymol. 2011. PMID: 21683260 Free PMC article. Review.
Viral cross-class serpin inhibits vascular inflammation and T lymphocyte fratricide; a study in rodent models in vivo and human cell lines in vitro.
Viswanathan K, Bot I, Liu L, Dai E, Turner PC, Togonu-Bickersteth B, Richardson J, Davids JA, Williams JM, Bartee MY, Chen H, van Berkel TJ, Biessen EA, Moyer RW, Lucas AR. Viswanathan K, et al. Among authors: chen h. PLoS One. 2012;7(9):e44694. doi: 10.1371/journal.pone.0044694. Epub 2012 Sep 26. PLoS One. 2012. PMID: 23049756 Free PMC article.
Myxomavirus anti-inflammatory chemokine binding protein reduces the increased plaque growth induced by chronic Porphyromonas gingivalis oral infection after balloon angioplasty aortic injury in mice.
Lucas AR, Verma RK, Dai E, Liu L, Chen H, Kesavalu S, Rivera M, Velsko I, Ambadapadi S, Chukkapalli S, Kesavalu L. Lucas AR, et al. Among authors: chen h. PLoS One. 2014 Oct 29;9(10):e111353. doi: 10.1371/journal.pone.0111353. eCollection 2014. PLoS One. 2014. PMID: 25354050 Free PMC article.
Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection.
Chen H, Zheng D, Abbott J, Liu L, Bartee MY, Long M, Davids J, Williams J, Feldmann H, Strong J, Grau KR, Tibbetts S, Macaulay C, McFadden G, Thoburn R, Lomas DA, Spinale FG, Virgin HW, Lucas A. Chen H, et al. Antimicrob Agents Chemother. 2013 Sep;57(9):4114-27. doi: 10.1128/AAC.02594-12. Epub 2013 Jun 17. Antimicrob Agents Chemother. 2013. PMID: 23774438 Free PMC article.
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