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γ-Secretase directly sheds the survival receptor BCMA from plasma cells.
Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E. Laurent SA, et al. Among authors: wanngren j. Nat Commun. 2015 Jun 11;6:7333. doi: 10.1038/ncomms8333. Nat Commun. 2015. PMID: 26065893 Free PMC article.
Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.
Rudan Njavro J, Klotz J, Dislich B, Wanngren J, Shmueli MD, Herber J, Kuhn PH, Kumar R, Koeglsperger T, Conrad M, Wurst W, Feederle R, Vlachos A, Michalakis S, Jedlicka P, Müller SA, Lichtenthaler SF. Rudan Njavro J, et al. Among authors: wanngren j. FASEB J. 2020 Feb;34(2):2465-2482. doi: 10.1096/fj.201902347R. Epub 2019 Dec 27. FASEB J. 2020. PMID: 31908000 Free article.
γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing.
Weber TA, Lundkvist J, Wanngren J, Kvartsberg H, Jin S, Larssen P, Wu D, Oliveira DV, Minta K, Brinkmalm G, Zetterberg H, Blennow K, Nordvall G, Winblad B, Portelius E, Karlström H. Weber TA, et al. Among authors: wanngren j. J Cell Mol Med. 2022 Feb;26(3):880-892. doi: 10.1111/jcmm.17146. Epub 2021 Dec 20. J Cell Mol Med. 2022. PMID: 34931449 Free PMC article.
The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.
Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H. Wanngren J, et al. J Biol Chem. 2010 Mar 19;285(12):8527-36. doi: 10.1074/jbc.M109.055590. Epub 2010 Jan 27. J Biol Chem. 2010. PMID: 20106965 Free PMC article.
Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.
Borgegård T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg AL, Rosqvist S, Serneels L, Svensson S, Olsson F, Jin S, Yan H, Wanngren J, Jureus A, Ridderstad-Wollberg A, Wollberg P, Stockling K, Karlström H, Malmberg A, Lund J, Arvidsson PI, De Strooper B, Lendahl U, Lundkvist J. Borgegård T, et al. Among authors: wanngren j. J Neurosci. 2012 Nov 28;32(48):17297-305. doi: 10.1523/JNEUROSCI.1451-12.2012. J Neurosci. 2012. PMID: 23197721 Free PMC article.