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Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.
Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE. Joyal JS, et al. Among authors: chen j. Nat Med. 2016 Apr;22(4):439-45. doi: 10.1038/nm.4059. Epub 2016 Mar 14. Nat Med. 2016. PMID: 26974308 Free PMC article.
SOCS3 is an endogenous inhibitor of pathologic angiogenesis.
Stahl A, Joyal JS, Chen J, Sapieha P, Juan AM, Hatton CJ, Pei DT, Hurst CG, Seaward MR, Krah NM, Dennison RJ, Greene ER, Boscolo E, Panigrahy D, Smith LE. Stahl A, et al. Among authors: chen j. Blood. 2012 Oct 4;120(14):2925-9. doi: 10.1182/blood-2012-04-422527. Epub 2012 Jul 12. Blood. 2012. PMID: 22791286 Free PMC article.
DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ω-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways.
SanGiovanni JP, Chen J, Sapieha P, Aderman CM, Stahl A, Clemons TE, Chew EY, Smith LE. SanGiovanni JP, et al. Among authors: chen j. PLoS One. 2013;8(1):e53155. doi: 10.1371/journal.pone.0053155. Epub 2013 Jan 15. PLoS One. 2013. PMID: 23335958 Free PMC article.
Choroid sprouting assay: an ex vivo model of microvascular angiogenesis.
Shao Z, Friedlander M, Hurst CG, Cui Z, Pei DT, Evans LP, Juan AM, Tahiri H, Duhamel F, Chen J, Sapieha P, Chemtob S, Joyal JS, Smith LE. Shao Z, et al. Among authors: chen j. PLoS One. 2013 Jul 26;8(7):e69552. doi: 10.1371/journal.pone.0069552. Print 2013. PLoS One. 2013. PMID: 23922736 Free PMC article.
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