McLean PJ - Search Results

1

Intracellular formation of α-synuclein oligomers and the effect of heat shock protein 70 characterized by confocal single particle spectroscopy.

Levin J, Hillmer AS, Högen T, McLean PJ, Giese A. Levin J, et al. Among authors: mclean pj. Biochem Biophys Res Commun. 2016 Aug 12;477(1):76-82. doi: 10.1016/j.bbrc.2016.06.023. Epub 2016 Jun 7. Biochem Biophys Res Commun. 2016. PMID: 27286709

2

Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.

McLean PJ, Klucken J, Shin Y, Hyman BT. McLean PJ, et al. Biochem Biophys Res Commun. 2004 Aug 27;321(3):665-9. doi: 10.1016/j.bbrc.2004.07.021. Biochem Biophys Res Commun. 2004. PMID: 15358157

3

A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.

Klucken J, Shin Y, Hyman BT, McLean PJ. Klucken J, et al. Among authors: mclean pj. Biochem Biophys Res Commun. 2004 Dec 3;325(1):367-73. doi: 10.1016/j.bbrc.2004.10.037. Biochem Biophys Res Commun. 2004. PMID: 15522241

4

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.

Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ. Outeiro TF, et al. Among authors: mclean pj. Biochem Biophys Res Commun. 2006 Dec 22;351(3):631-8. doi: 10.1016/j.bbrc.2006.10.085. Epub 2006 Oct 26. Biochem Biophys Res Commun. 2006. PMID: 17081499 Free PMC article.

5

CHIP targets toxic alpha-Synuclein oligomers for degradation.

Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ. Tetzlaff JE, et al. Among authors: mclean pj. J Biol Chem. 2008 Jun 27;283(26):17962-8. doi: 10.1074/jbc.M802283200. Epub 2008 Apr 24. J Biol Chem. 2008. PMID: 18436529 Free PMC article.

6

Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron.

Hillmer AS, Putcha P, Levin J, Högen T, Hyman BT, Kretzschmar H, McLean PJ, Giese A. Hillmer AS, et al. Among authors: mclean pj. Biochem Biophys Res Commun. 2010 Jan 1;391(1):461-6. doi: 10.1016/j.bbrc.2009.11.080. Epub 2009 Nov 13. Biochem Biophys Res Commun. 2010. PMID: 19914207 Free PMC article.

7

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.

Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ. Danzer KM, et al. Among authors: mclean pj. FASEB J. 2011 Jan;25(1):326-36. doi: 10.1096/fj.10-164624. Epub 2010 Sep 27. FASEB J. 2011. PMID: 20876215 Free PMC article.

8

Alpha-synuclein and tau: teammates in neurodegeneration?

Moussaud S, Jones DR, Moussaud-Lamodière EL, Delenclos M, Ross OA, McLean PJ. Moussaud S, et al. Among authors: mclean pj. Mol Neurodegener. 2014 Oct 29;9:43. doi: 10.1186/1750-1326-9-43. Mol Neurodegener. 2014. PMID: 25352339 Free PMC article. Review.

9

Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies.

Moussaud S, Malany S, Mehta A, Vasile S, Smith LH, McLean PJ. Moussaud S, et al. Among authors: mclean pj. Expert Opin Ther Targets. 2015 May;19(5):589-603. doi: 10.1517/14728222.2015.1009448. Epub 2015 Mar 18. Expert Opin Ther Targets. 2015. PMID: 25785645 Free PMC article.

10

Histones facilitate α-synuclein aggregation during neuronal apoptosis.

Jiang P, Gan M, Yen SH, McLean PJ, Dickson DW. Jiang P, et al. Among authors: mclean pj. Acta Neuropathol. 2017 Apr;133(4):547-558. doi: 10.1007/s00401-016-1660-z. Epub 2016 Dec 21. Acta Neuropathol. 2017. PMID: 28004278 Free PMC article.

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