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Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration.
Yaspan BL, Williams DF, Holz FG, Regillo CD, Li Z, Dressen A, van Lookeren Campagne M, Le KN, Graham RR, Beres T, Bhangale TR, Honigberg LA, Smith A, Henry EC, Ho C, Strauss EC; MAHALO Study Investigators. Yaspan BL, et al. Among authors: van lookeren campagne m. Sci Transl Med. 2017 Jun 21;9(395):eaaf1443. doi: 10.1126/scitranslmed.aaf1443. Sci Transl Med. 2017. PMID: 28637922 Clinical Trial.
Age-related macular degeneration: Complement in action.
van Lookeren Campagne M, Strauss EC, Yaspan BL. van Lookeren Campagne M, et al. Immunobiology. 2016 Jun;221(6):733-9. doi: 10.1016/j.imbio.2015.11.007. Epub 2015 Dec 19. Immunobiology. 2016. PMID: 26742632 Free article. Review.
Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy.
Katschke KJ Jr, Xi H, Cox C, Truong T, Malato Y, Lee WP, McKenzie B, Arceo R, Tao J, Rangell L, Reichelt M, Diehl L, Elstrott J, Weimer RM, van Lookeren Campagne M. Katschke KJ Jr, et al. Among authors: van lookeren campagne m. Sci Rep. 2018 May 9;8(1):7348. doi: 10.1038/s41598-018-25557-8. Sci Rep. 2018. PMID: 29743491 Free PMC article.
Complement inhibition in cynomolgus monkeys by anti-factor d antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration.
Loyet KM, Good J, Davancaze T, Sturgeon L, Wang X, Yang J, Le KN, Wong M, Hass PE, van Lookeren Campagne M, Haughney PC, Morimoto A, Damico-Beyer LA, DeForge LE. Loyet KM, et al. Among authors: van lookeren campagne m. J Pharmacol Exp Ther. 2014 Dec;351(3):527-37. doi: 10.1124/jpet.114.215921. Epub 2014 Sep 17. J Pharmacol Exp Ther. 2014. PMID: 25232192
117 results