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Demonstration of In Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorus Chemical Nerve Agents.
Zhuang Q, Franjesevic AJ, Corrigan TS, Coldren WH, Dicken R, Sillart S, DeYong A, Yoshino N, Smith J, Fabry S, Fitzpatrick K, Blanton TG, Joseph J, Yoder RJ, McElroy CA, Ekici ÖD, Callam CS, Hadad CM. Zhuang Q, et al. Among authors: mcelroy ca. J Med Chem. 2018 Aug 23;61(16):7034-7042. doi: 10.1021/acs.jmedchem.7b01620. Epub 2018 Jun 20. J Med Chem. 2018. PMID: 29870665
Study of para-Quinone Methide Precursors toward the Realkylation of Aged Acetylcholinesterase.
Yoder RJ, Zhuang Q, Beck JM, Franjesevic A, Blanton TG, Sillart S, Secor T, Guerra L, Brown JD, Reid C, McElroy CA, Doğan Ekici Ö, Callam CS, Hadad CM. Yoder RJ, et al. Among authors: mcelroy ca. ACS Med Chem Lett. 2017 May 8;8(6):622-627. doi: 10.1021/acsmedchemlett.7b00037. eCollection 2017 Jun 8. ACS Med Chem Lett. 2017. PMID: 28626522 Free PMC article.
Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors.
Corrigan TS, Lotti Diaz LM, Border SE, Ratigan SC, Kasper KQ, Sojka D, Fajtova P, Caffrey CR, Salvesen GS, McElroy CA, Hadad CM, Doğan Ekici Ö. Corrigan TS, et al. Among authors: mcelroy ca. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1387-1402. doi: 10.1080/14756366.2020.1781107. J Enzyme Inhib Med Chem. 2020. PMID: 32633155 Free PMC article.
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.
Lu Y, Vibhute S, Li L, Okumu A, Ratigan SC, Nolan S, Papa JL, Mann CA, English A, Chen A, Seffernick JT, Koci B, Duncan LR, Roth B, Cummings JE, Slayden RA, Lindert S, McElroy CA, Wozniak DJ, Yalowich J, Mitton-Fry MJ. Lu Y, et al. Among authors: mcelroy ca. J Med Chem. 2021 Oct 28;64(20):15214-15249. doi: 10.1021/acs.jmedchem.1c01250. Epub 2021 Oct 6. J Med Chem. 2021. PMID: 34614347
In-silico guided design, screening, and molecular dynamic simulation studies for the identification of potential SARS-CoV-2 main protease inhibitors for the targeted treatment of COVID-19.
Gutti G, He Y, Coldren WH, Lalisse RF, Border SE, Hadad CM, McElroy CA, Ekici ÖD. Gutti G, et al. Among authors: mcelroy ca. J Biomol Struct Dyn. 2024 Feb-Mar;42(4):1733-1750. doi: 10.1080/07391102.2023.2202247. Epub 2023 Apr 28. J Biomol Struct Dyn. 2024. PMID: 37114441
Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase.
Clay WK, Buck AK, He Y, Hernández Sánchez DN, Ward NA, Lear JM, Nguyen KQ, Clark BH, Sapia RJ, Lalisse RF, Sriraman A, Cadieux CL, McElroy CA, Callam CS, Hadad CM. Clay WK, et al. Among authors: mcelroy ca. Chem Res Toxicol. 2024 Apr 15;37(4):643-657. doi: 10.1021/acs.chemrestox.4c00024. Epub 2024 Mar 31. Chem Res Toxicol. 2024. PMID: 38556765
4-Amidophenol Quinone Methide Precursors: Effective and Broad-Scope Nonoxime Reactivators of Organophosphorus-Inhibited Cholinesterases and Resurrectors of Organophosphorus-Aged Acetylcholinesterase.
Lovins AR, Miller KA, Buck AK, Ensey DS, Homoelle RK, Murtha MC, Ward NA, Shanahan LA, Gutti G, Shriwas P, McElroy CA, Callam CS, Hadad CM. Lovins AR, et al. Among authors: mcelroy ca. ACS Chem Neurosci. 2024 May 1;15(9):1813-1827. doi: 10.1021/acschemneuro.4c00011. Epub 2024 Apr 15. ACS Chem Neurosci. 2024. PMID: 38621296
43 results