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HIV proviral DNA integration can drive T cell growth ex vivo.
Yoon JK, Holloway JR, Wells DW, Kaku M, Jetton D, Brown R, Coffin JM. Yoon JK, et al. Among authors: wells dw. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):32880-32882. doi: 10.1073/pnas.2013194117. Epub 2020 Dec 14. Proc Natl Acad Sci U S A. 2020. PMID: 33318172 Free PMC article.
HIV-1 in lymph nodes is maintained by cellular proliferation during antiretroviral therapy.
McManus WR, Bale MJ, Spindler J, Wiegand A, Musick A, Patro SC, Sobolewski MD, Musick VK, Anderson EM, Cyktor JC, Halvas EK, Shao W, Wells D, Wu X, Keele BF, Milush JM, Hoh R, Mellors JW, Hughes SH, Deeks SG, Coffin JM, Kearney MF. McManus WR, et al. J Clin Invest. 2019 Jul 30;129(11):4629-4642. doi: 10.1172/JCI126714. J Clin Invest. 2019. PMID: 31361603 Free PMC article. Clinical Trial.
Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy.
Coffin JM, Bale MJ, Wells D, Guo S, Luke B, Zerbato JM, Sobolewski MD, Sia T, Shao W, Wu X, Maldarelli F, Kearney MF, Mellors JW, Hughes SH. Coffin JM, et al. PLoS Pathog. 2021 Apr 7;17(4):e1009141. doi: 10.1371/journal.ppat.1009141. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33826675 Free PMC article.
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