Kirkland JL - Search Results

1

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype.

Zhang B, Long Q, Wu S, Xu Q, Song S, Han L, Qian M, Ren X, Liu H, Jiang J, Guo J, Zhang X, Chang X, Fu Q, Lam EW, Campisi J, Kirkland JL, Sun Y. Zhang B, et al. Among authors: kirkland jl. Nat Aging. 2021 May;1(5):454-472. doi: 10.1038/s43587-021-00063-1. Epub 2021 May 13. Nat Aging. 2021. PMID: 34263179 Free PMC article.

2

Fat tissue, aging, and cellular senescence.

Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen MD, Kirkland JL. Tchkonia T, et al. Among authors: kirkland jl. Aging Cell. 2010 Oct;9(5):667-84. doi: 10.1111/j.1474-9726.2010.00608.x. Epub 2010 Aug 15. Aging Cell. 2010. PMID: 20701600 Free PMC article. Review.

3

Perspectives on cellular senescence and short term dietary restriction in adults.

Kirkland JL. Kirkland JL. Aging (Albany NY). 2010 Sep;2(9):542-4. doi: 10.18632/aging.100204. Aging (Albany NY). 2010. PMID: 20864777 Free PMC article. No abstract available.

4

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Baker DJ, et al. Among authors: kirkland jl. Nature. 2011 Nov 2;479(7372):232-6. doi: 10.1038/nature10600. Nature. 2011. PMID: 22048312 Free PMC article.

5

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.

Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Tchkonia T, et al. Among authors: kirkland jl. J Clin Invest. 2013 Mar;123(3):966-72. doi: 10.1172/JCI64098. Epub 2013 Mar 1. J Clin Invest. 2013. PMID: 23454759 Free PMC article. Review.

6

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases.

Zhu Y, Armstrong JL, Tchkonia T, Kirkland JL. Zhu Y, et al. Among authors: kirkland jl. Curr Opin Clin Nutr Metab Care. 2014 Jul;17(4):324-8. doi: 10.1097/MCO.0000000000000065. Curr Opin Clin Nutr Metab Care. 2014. PMID: 24848532 Review.

7

Senescence and apoptosis: dueling or complementary cell fates?

Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM. Childs BG, et al. Among authors: kirkland jl. EMBO Rep. 2014 Nov;15(11):1139-53. doi: 10.15252/embr.201439245. Epub 2014 Oct 13. EMBO Rep. 2014. PMID: 25312810 Free PMC article. Review.

8

New agents that target senescent cells: the flavone, fisetin, and the BCL-X_L inhibitors, A1331852 and A1155463.

Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD, Tchkonia T, Kirkland JL. Zhu Y, et al. Among authors: kirkland jl. Aging (Albany NY). 2017 Mar 8;9(3):955-963. doi: 10.18632/aging.101202. Aging (Albany NY). 2017. PMID: 28273655 Free PMC article.

9

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion.

Kandhaya-Pillai R, Miro-Mur F, Alijotas-Reig J, Tchkonia T, Kirkland JL, Schwartz S. Kandhaya-Pillai R, et al. Among authors: kirkland jl. Aging (Albany NY). 2017 Nov 22;9(11):2411-2435. doi: 10.18632/aging.101328. Aging (Albany NY). 2017. PMID: 29176033 Free PMC article.

10

Aged-senescent cells contribute to impaired heart regeneration.

Lewis-McDougall FC, Ruchaya PJ, Domenjo-Vila E, Shin Teoh T, Prata L, Cottle BJ, Clark JE, Punjabi PP, Awad W, Torella D, Tchkonia T, Kirkland JL, Ellison-Hughes GM. Lewis-McDougall FC, et al. Among authors: kirkland jl. Aging Cell. 2019 Jun;18(3):e12931. doi: 10.1111/acel.12931. Epub 2019 Mar 10. Aging Cell. 2019. PMID: 30854802 Free PMC article.

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