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Non-cytotoxic 3-Acetylcoumarin as an Attractive Target for Human Monoamine Oxidase (HMAO) Enzymes.
Aghimien MO, Kolawole Q, Igbinoba PO, Musa MA, Latinwo L. Aghimien MO, et al. Anticancer Res. 2024 Jun;44(6):2335-2341. doi: 10.21873/anticanres.17040. Anticancer Res. 2024. PMID: 38821578
BACKGROUND/AIM: Coumarins are a broad class of naturally occurring oxygen-heterocyclic compounds found in plants with diverse biological properties, making them attractive for evaluation as novel therapeutic agents. We herein report the in vitro cytotoxic and monoamine …
BACKGROUND/AIM: Coumarins are a broad class of naturally occurring oxygen-heterocyclic compounds found in plants with diverse biological pro …
Design and discovery of anthranilamide derivatives as a potential treatment for neurodegenerative disorders via targeting cholinesterases and monoamine oxidases.
Zaib S, Khan I, Ali HS, Younas MT, Ibrar A, Al-Odayni AB, Al-Kahtani AA. Zaib S, et al. Int J Biol Macromol. 2024 May 29:132748. doi: 10.1016/j.ijbiomac.2024.132748. Online ahead of print. Int J Biol Macromol. 2024. PMID: 38821306
Neurodegenerative diseases with progressive cellular loss of the central nervous system and elusive disease etiology provide a continuous impetus to explore drug discovery programmes aiming at identifying robust and effective inhibitors of cholinesterase and monoamine o …
Neurodegenerative diseases with progressive cellular loss of the central nervous system and elusive disease etiology provide a continuous im …
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization.
La Spada G, Miniero DV, Rullo M, Cipolloni M, Delre P, Colliva C, Colella M, Leonetti F, Liuzzi GM, Mangiatordi GF, Giacchè N, Pisani L. La Spada G, et al. Eur J Med Chem. 2024 May 19;274:116511. doi: 10.1016/j.ejmech.2024.116511. Online ahead of print. Eur J Med Chem. 2024. PMID: 38820854
A structure-based drug design approach was focused on incorporating phenyl ring heterocyclic bioisosteres into coumarin derivative 1, previously reported as potent dual AChE-MAO B inhibitor, with the aim of improving drug-like features. Structure-activity relationsh …
A structure-based drug design approach was focused on incorporating phenyl ring heterocyclic bioisosteres into coumarin derivative 1, previo …
Dietary supplement for mood symptoms in early postpartum: a double-blind randomized placebo controlled trial.
Meyer JH, Wang Z, Santhirakumar A, Dowlati Y, Docteur N, Shoaib A, Purnava J, Wang Y, Wang W, Chen S, Husain MI, de Silva Wijeyeratne R, Reeyaz H, Baena-Tan C, Koshimori Y, Nasser Z, Sit V. Meyer JH, et al. EClinicalMedicine. 2024 Apr 10;71:102593. doi: 10.1016/j.eclinm.2024.102593. eCollection 2024 May. EClinicalMedicine. 2024. PMID: 38813444 Free PMC article.
The supplement was designed to counter downstream effects of elevated monoamine oxidase A level, implicated in causing PPB. METHODS: Participants recruited by advertisement from the Toronto region completed procedures at CAMH, Canada and/or participants' homes. ...
The supplement was designed to counter downstream effects of elevated monoamine oxidase A level, implicated in causing PPB. ME …
27,014 results
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