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Inflammasome activation in infected macrophages drives COVID-19 pathology.
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Sefik E, et al. Among authors: iwasaki a. Nature. 2022 Jun;606(7914):585-593. doi: 10.1038/s41586-022-04802-1. Epub 2022 Apr 28. Nature. 2022. PMID: 35483404 Free PMC article.
Recognition of single-stranded RNA viruses by Toll-like receptor 7.
Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A, Flavell RA. Lund JM, et al. Among authors: iwasaki a. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5598-603. doi: 10.1073/pnas.0400937101. Epub 2004 Mar 19. Proc Natl Acad Sci U S A. 2004. PMID: 15034168 Free PMC article.
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.
Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Rongvaux A, et al. Among authors: iwasaki a. Cell. 2014 Dec 18;159(7):1563-77. doi: 10.1016/j.cell.2014.11.037. Cell. 2014. PMID: 25525875 Free PMC article.
Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.
Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A. Pillai PS, et al. Among authors: iwasaki a. Science. 2016 Apr 22;352(6284):463-6. doi: 10.1126/science.aaf3926. Science. 2016. PMID: 27102485 Free PMC article.
1,134 results