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A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections.
Blaskovich MAT, Hansford KA, Butler MS, Ramu S, Kavanagh AM, Jarrad AM, Prasetyoputri A, Pitt ME, Huang JX, Lindahl F, Ziora ZM, Bradford T, Muldoon C, Rajaratnam P, Pelingon R, Edwards DJ, Zhang B, Amado M, Elliott AG, Zuegg J, Coin L, Woischnig AK, Khanna N, Breidenstein E, Stincone A, Mason C, Khan N, Cho HK, Karau MJ, Greenwood-Quaintance KE, Patel R, Wootton M, James ML, Hutton ML, Lyras D, Ogunniyi AD, Mahdi LK, Trott DJ, Wu X, Niles S, Lewis K, Smith JR, Barber KE, Yim J, Rice SA, Rybak MJ, Ishmael CR, Hori KR, Bernthal NM, Francis KP, Roberts JA, Paterson DL, Cooper MA. Blaskovich MAT, et al. Among authors: lewis k. Sci Transl Med. 2022 Sep 14;14(662):eabj2381. doi: 10.1126/scitranslmed.abj2381. Epub 2022 Sep 14. Sci Transl Med. 2022. PMID: 36103517
Persister cells in biofilm associated infections.
Conlon BP, Rowe SE, Lewis K. Conlon BP, et al. Among authors: lewis k. Adv Exp Med Biol. 2015;831:1-9. doi: 10.1007/978-3-319-09782-4_1. Adv Exp Med Biol. 2015. PMID: 25384659 Review. No abstract available.
A new antibiotic selectively kills Gram-negative pathogens.
Imai Y, Meyer KJ, Iinishi A, Favre-Godal Q, Green R, Manuse S, Caboni M, Mori M, Niles S, Ghiglieri M, Honrao C, Ma X, Guo JJ, Makriyannis A, Linares-Otoya L, Böhringer N, Wuisan ZG, Kaur H, Wu R, Mateus A, Typas A, Savitski MM, Espinoza JL, O'Rourke A, Nelson KE, Hiller S, Noinaj N, Schäberle TF, D'Onofrio A, Lewis K. Imai Y, et al. Among authors: lewis k. Nature. 2019 Dec;576(7787):459-464. doi: 10.1038/s41586-019-1791-1. Epub 2019 Nov 20. Nature. 2019. PMID: 31747680 Free PMC article.
A selective antibiotic for Lyme disease.
Leimer N, Wu X, Imai Y, Morrissette M, Pitt N, Favre-Godal Q, Iinishi A, Jain S, Caboni M, Leus IV, Bonifay V, Niles S, Bargabos R, Ghiglieri M, Corsetti R, Krumpoch M, Fox G, Son S, Klepacki D, Polikanov YS, Freliech CA, McCarthy JE, Edmondson DG, Norris SJ, D'Onofrio A, Hu LT, Zgurskaya HI, Lewis K. Leimer N, et al. Among authors: lewis k. Cell. 2021 Oct 14;184(21):5405-5418.e16. doi: 10.1016/j.cell.2021.09.011. Epub 2021 Oct 6. Cell. 2021. PMID: 34619078 Free PMC article.
Computational identification of a systemic antibiotic for gram-negative bacteria.
Miller RD, Iinishi A, Modaresi SM, Yoo BK, Curtis TD, Lariviere PJ, Liang L, Son S, Nicolau S, Bargabos R, Morrissette M, Gates MF, Pitt N, Jakob RP, Rath P, Maier T, Malyutin AG, Kaiser JT, Niles S, Karavas B, Ghiglieri M, Bowman SEJ, Rees DC, Hiller S, Lewis K. Miller RD, et al. Among authors: lewis k. Nat Microbiol. 2022 Oct;7(10):1661-1672. doi: 10.1038/s41564-022-01227-4. Epub 2022 Sep 26. Nat Microbiol. 2022. PMID: 36163500 Free PMC article.
Activated ClpP kills persisters and eradicates a chronic biofilm infection.
Conlon BP, Nakayasu ES, Fleck LE, LaFleur MD, Isabella VM, Coleman K, Leonard SN, Smith RD, Adkins JN, Lewis K. Conlon BP, et al. Among authors: lewis k. Nature. 2013 Nov 21;503(7476):365-70. doi: 10.1038/nature12790. Epub 2013 Nov 13. Nature. 2013. PMID: 24226776 Free PMC article.
2,474 results