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BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors.
Mol Cancer Ther. 2022 Dec 2;21(12):1747-1756. doi: 10.1158/1535-7163.MCT-21-0875.
Mol Cancer Ther. 2022.
PMID: 36112771
Free PMC article.
Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads.
Mudd GE, Brown A, Chen L, van Rietschoten K, Watcham S, Teufel DP, Pavan S, Lani R, Huxley P, Bennett GS.
Mudd GE, et al.
J Med Chem. 2020 Apr 23;63(8):4107-4116. doi: 10.1021/acs.jmedchem.9b02129. Epub 2020 Apr 2.
J Med Chem. 2020.
PMID: 32202781
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MMAE Delivery Using the Bicycle Toxin Conjugate BT5528.
Bennett G, Brown A, Mudd G, Huxley P, Van Rietschoten K, Pavan S, Chen L, Watcham S, Lahdenranta J, Keen N.
Bennett G, et al.
Mol Cancer Ther. 2020 Jul;19(7):1385-1394. doi: 10.1158/1535-7163.MCT-19-1092. Epub 2020 May 12.
Mol Cancer Ther. 2020.
PMID: 32398269
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Discovery of BT8009: A Nectin-4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer.
Mudd GE, Scott H, Chen L, van Rietschoten K, Ivanova-Berndt G, Dzionek K, Brown A, Watcham S, White L, Park PU, Jeffrey P, Rigby M, Beswick P.
Mudd GE, et al.
J Med Chem. 2022 Nov 10;65(21):14337-14347. doi: 10.1021/acs.jmedchem.2c00065. Epub 2022 Oct 6.
J Med Chem. 2022.
PMID: 36204777
Free PMC article.
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Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin.
Narjes F, Edfeldt F, Petersen J, Öster L, Hamblet C, Bird J, Bold P, Rae R, Bäck E, Stomilovic S, Zlatoidsky P, Svensson T, Hidestål L, Kunalingam L, Shamovsky I, De Maria L, Gordon E, Lewis RJ, Watcham S, van Rietschoten K, Mudd GE, Harrison H, Chen L, Skynner MJ.
Narjes F, et al.
J Med Chem. 2024 Feb 8;67(3):2220-2235. doi: 10.1021/acs.jmedchem.3c02163. Epub 2024 Jan 29.
J Med Chem. 2024.
PMID: 38284169
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