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mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome.
Huang Z, You X, Chen L, Du Y, Brodeur K, Jee H, Wang Q, Linder G, Darbousset R, Cunin P, Chang MH, Wactor A, Wauford BM, Todd MJC, Wei K, Li Y, Levescot A, Iwakura Y, Pascual V, Baldwin NE, Quartier P, Li T, Gianatasio MT, Hasserjian RP, Henderson LA, Sykes DB, Mellins ED, Canna SW, Charles JF, Nigrovic PA, Lee PY. Huang Z, et al. Among authors: wei k. Nat Commun. 2022 Nov 28;13(1):6915. doi: 10.1038/s41467-022-34480-6. Nat Commun. 2022. PMID: 36443301 Free PMC article.
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis.
Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB. Rao DA, et al. Among authors: wei k. Nature. 2017 Feb 1;542(7639):110-114. doi: 10.1038/nature20810. Nature. 2017. PMID: 28150777 Free PMC article.
The metabolic regulator mTORC1 controls terminal myeloid differentiation.
Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. Lee PY, et al. Among authors: wei k. Sci Immunol. 2017 May 26;2(11):eaam6641. doi: 10.1126/sciimmunol.aam6641. Sci Immunol. 2017. PMID: 28763796 Free PMC article.
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.
Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB. Mizoguchi F, et al. Among authors: wei k. Nat Commun. 2018 Feb 23;9(1):789. doi: 10.1038/s41467-018-02892-y. Nat Commun. 2018. PMID: 29476097 Free PMC article.
Notch signalling drives synovial fibroblast identity and arthritis pathology.
Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT; Accelerating Medicines Partnership Rheumatoid Arthritis & Systemic Lupus Erythematosus (AMP RA/SLE) Consortium; Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB. Wei K, et al. Nature. 2020 Jun;582(7811):259-264. doi: 10.1038/s41586-020-2222-z. Epub 2020 Apr 22. Nature. 2020. PMID: 32499639 Free PMC article.
IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis.
Levescot A, Chang MH, Schnell J, Nelson-Maney N, Yan J, Martínez-Bonet M, Grieshaber-Bouyer R, Lee PY, Wei K, Blaustein RB, Morris A, Wactor A, Iwakura Y, Lederer JA, Rao DA, Charles JF, Nigrovic PA. Levescot A, et al. Among authors: wei k. J Clin Invest. 2021 Sep 15;131(18):e141008. doi: 10.1172/JCI141008. J Clin Invest. 2021. PMID: 34343136 Free PMC article.
Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis.
Julé AM, Hoyt KJ, Wei K, Gutierrez-Arcelus M, Taylor ML, Ng J, Lederer JA, Case SM, Chang MH, Cohen EM, Dedeoglu F, Hazen MM, Hausmann JS, Halyabar O, Janssen E, Lo J, Lo MS, Meidan E, Roberts JE, Son MBF, Sundel RP, Lee PY, Chatila T, Nigrovic PA, Henderson LA. Julé AM, et al. Among authors: wei k. JCI Insight. 2021 Sep 22;6(18):e149185. doi: 10.1172/jci.insight.149185. JCI Insight. 2021. PMID: 34403374 Free PMC article.
Arthritis flares mediated by tissue-resident memory T cells in the joint.
Chang MH, Levescot A, Nelson-Maney N, Blaustein RB, Winden KD, Morris A, Wactor A, Balu S, Grieshaber-Bouyer R, Wei K, Henderson LA, Iwakura Y, Clark RA, Rao DA, Fuhlbrigge RC, Nigrovic PA. Chang MH, et al. Among authors: wei k. Cell Rep. 2021 Oct 26;37(4):109902. doi: 10.1016/j.celrep.2021.109902. Cell Rep. 2021. PMID: 34706228 Free PMC article.
2,685 results