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Step-wise activation of a Family C GPCR.
Kumar KK, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK. Kumar KK, et al. Among authors: kobilka bk. bioRxiv [Preprint]. 2023 Aug 30:2023.08.29.555158. doi: 10.1101/2023.08.29.555158. bioRxiv. 2023. PMID: 37693614 Free PMC article. Preprint.
Negative allosteric modulation of the glucagon receptor by RAMP2.
Krishna Kumar K, O'Brien ES, Habrian CH, Latorraca NR, Wang H, Tuneew I, Montabana E, Marqusee S, Hilger D, Isacoff EY, Mathiesen JM, Kobilka BK. Krishna Kumar K, et al. Among authors: kobilka bk. Cell. 2023 Mar 30;186(7):1465-1477.e18. doi: 10.1016/j.cell.2023.02.028. Cell. 2023. PMID: 37001505 Free PMC article.
Structure and dynamics determine G protein coupling specificity at a class A GPCR.
Casiraghi M, Wang H, Brennan P, Habrian C, Hubner H, Schmidt MF, Maul L, Pani B, Bahriz SM, Xu B, White E, Sunahara RK, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch M, Kobilka BK. Casiraghi M, et al. Among authors: kobilka bk. bioRxiv [Preprint]. 2024 Apr 12:2024.03.28.587240. doi: 10.1101/2024.03.28.587240. bioRxiv. 2024. PMID: 38586060 Free PMC article. Preprint.
Author Correction: Stepwise activation of a metabotropic glutamate receptor.
Krishna Kumar K, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK. Krishna Kumar K, et al. Among authors: kobilka bk. Nature. 2024 May;629(8013):E13. doi: 10.1038/s41586-024-07470-5. Nature. 2024. PMID: 38702522 No abstract available.
Stepwise activation of a metabotropic glutamate receptor.
Krishna Kumar K, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK. Krishna Kumar K, et al. Among authors: kobilka bk. Nature. 2024 May;629(8013):951-956. doi: 10.1038/s41586-024-07327-x. Epub 2024 Apr 17. Nature. 2024. PMID: 38632403
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor.
Zhao J, Elgeti M, O'Brien ES, Sár CP, Ei Daibani A, Heng J, Sun X, White E, Che T, Hubbell WL, Kobilka BK, Chen C. Zhao J, et al. Among authors: kobilka bk. Nature. 2024 May;629(8011):474-480. doi: 10.1038/s41586-024-07295-2. Epub 2024 Apr 10. Nature. 2024. PMID: 38600384 Free PMC article.
Time-resolved cryo-EM of G-protein activation by a GPCR.
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Papasergi-Scott MM, et al. Among authors: kobilka bk. Nature. 2024 May;629(8014):1182-1191. doi: 10.1038/s41586-024-07153-1. Epub 2024 Mar 13. Nature. 2024. PMID: 38480881
Molecular determinants of ligand efficacy and potency in GPCR signaling.
Heydenreich FM, Marti-Solano M, Sandhu M, Kobilka BK, Bouvier M, Babu MM. Heydenreich FM, et al. Among authors: kobilka bk. Science. 2023 Dec 22;382(6677):eadh1859. doi: 10.1126/science.adh1859. Epub 2023 Dec 22. Science. 2023. PMID: 38127743 Free PMC article.
291 results