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Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.
Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S; Long‐Life Family Study (LLFS); Alzheimer's Disease Genetic Consortium (ADGC); Alzheimer's Biomarkers Consortium‐Down Syndrome (ABC‐DS). Xicota L, et al. Among authors: christian bt. Alzheimers Dement. 2024 Apr;20(4):2670-2679. doi: 10.1002/alz.13718. Epub 2024 Feb 21. Alzheimers Dement. 2024. PMID: 38380866 Free PMC article.
Plasma NT1-tau and Aβ 42 correlate with age and cognitive function in two large Down syndrome cohorts.
Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E; Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS) investigators. Stern AM, et al. Among authors: christian bt. medRxiv [Preprint]. 2023 Mar 10:2023.03.10.23287109. doi: 10.1101/2023.03.10.23287109. medRxiv. 2023. PMID: 36945447 Free PMC article. Updated. Preprint.
Plasma phosphorylated tau 217 in preclinical Alzheimer's disease.
Jonaitis EM, Janelidze S, Cody KA, Langhough R, Du L, Chin NA, Mattsson-Carlgren N, Hogan KJ, Christian BT, Betthauser TJ, Hansson O, Johnson SC. Jonaitis EM, et al. Among authors: christian bt. Brain Commun. 2023 Mar 6;5(2):fcad057. doi: 10.1093/braincomms/fcad057. eCollection 2023. Brain Commun. 2023. PMID: 37013174 Free PMC article.
Plasma NT1-tau and Aβ42 correlate with age and cognitive function in two large Down syndrome cohorts.
Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E; Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) investigators. Stern AM, et al. Among authors: christian bt. Alzheimers Dement. 2023 Dec;19(12):5755-5764. doi: 10.1002/alz.13382. Epub 2023 Jul 12. Alzheimers Dement. 2023. PMID: 37438872
Timing of Alzheimer's Disease by Intellectual Disability Level in Down Syndrome.
Hartley SL, Fleming V, Schworer EK, Peven J, Handen BL, Krinsky-McHale S, Hom C, Lee L, Tudorascu DL, Laymon C, Minhas D, Luo W, Cohen A, Zaman S, Ances BM, Mapstone M, Head E, Lai F, Rosas HD, Klunk W, Christian B; Alzheimer Biomarker Consortium-Down Syndrome. Hartley SL, et al. J Alzheimers Dis. 2023;95(1):213-225. doi: 10.3233/JAD-230200. J Alzheimers Dis. 2023. PMID: 37482997 Free PMC article.
AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome.
Hartley SL, Handen B, Tudorascu D, Lee L, Cohen A, Schworer EK, Peven JC, Zammit M, Klunk W, Laymon C, Minhas D, Luo W, Zaman S, Ances B, Preboske G, Christian BT; Alzheimer Biomarker Consortium - Down Syndrome. Hartley SL, et al. Among authors: christian bt. Alzheimers Dement. 2024 Jan;20(1):366-375. doi: 10.1002/alz.13446. Epub 2023 Aug 28. Alzheimers Dement. 2024. PMID: 37641428 Free PMC article.
Characterizing the emergence of amyloid and tau burden in Down syndrome.
Zammit MD, Betthauser TJ, McVea AK, Laymon CM, Tudorascu DL, Johnson SC, Hartley SL, Converse AK, Minhas DS, Zaman SH, Ances BM, Stone CK, Mathis CA, Cohen AD, Klunk WE, Handen BL, Christian BT; Alzheimer's Biomarker Consortium - Down Syndrome. Zammit MD, et al. Among authors: christian bt. Alzheimers Dement. 2024 Jan;20(1):388-398. doi: 10.1002/alz.13444. Epub 2023 Aug 29. Alzheimers Dement. 2024. PMID: 37641577 Free PMC article.
Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome.
Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Flores-Aguilar L, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA, Gutierrez J, Wilcock DM, Head E, Brickman AM. Edwards NC, et al. Among authors: christian bt. medRxiv [Preprint]. 2023 Nov 30:2023.11.28.23298693. doi: 10.1101/2023.11.28.23298693. medRxiv. 2023. PMID: 38076904 Free PMC article. Preprint.
190 results