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The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.
Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H, Ishihara H, Asano T. Nakatsu Y, et al. J Biol Chem. 2017 Jul 14;292(28):11886-11895. doi: 10.1074/jbc.M117.780726. Epub 2017 May 31. J Biol Chem. 2017. PMID: 28566287 Free PMC article.
Development of Pin1 Inhibitors and their Potential as Therapeutic Agents.
Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK, Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T. Nakatsu Y, et al. Curr Med Chem. 2020;27(20):3314-3329. doi: 10.2174/0929867325666181105120911. Curr Med Chem. 2020. PMID: 30394205 Review.
Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.
Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T. Nakatsu Y, et al. Cell Rep. 2019 Mar 19;26(12):3221-3230.e3. doi: 10.1016/j.celrep.2019.02.066. Cell Rep. 2019. PMID: 30893596 Free article.
Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation.
Ueda K, Nakatsu Y, Yamamotoya T, Ono H, Inoue Y, Inoue MK, Mizuno Y, Matsunaga Y, Kushiyama A, Sakoda H, Fujishiro M, Takahashi SI, Matsubara A, Asano T. Ueda K, et al. Among authors: nakatsu y. Oncotarget. 2019 Feb 26;10(17):1637-1648. doi: 10.18632/oncotarget.26691. eCollection 2019 Feb 26. Oncotarget. 2019. PMID: 30899433 Free PMC article.
Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells.
Nakatsu Y, Yamamotoya T, Ueda K, Ono H, Inoue MK, Matsunaga Y, Kushiyama A, Sakoda H, Fujishiro M, Matsubara A, Asano T. Nakatsu Y, et al. Cancer Lett. 2020 Feb 1;470:106-114. doi: 10.1016/j.canlet.2019.10.043. Epub 2019 Oct 31. Cancer Lett. 2020. PMID: 31678165 Review.
205 results