Wells G - Search Results

1

Synthesis and biological activity of a series of potent fluoromethyl ketone inhibitors of recombinant human calpain I.

Chatterjee S, Ator MA, Bozyczko-Coyne D, Josef K, Wells G, Tripathy R, Iqbal M, Bihovsky R, Senadhi SE, Mallya S, O'Kane TM, McKenna BA, Siman R, Mallamo JP. Chatterjee S, et al. Among authors: wells g. J Med Chem. 1997 Nov 7;40(23):3820-8. doi: 10.1021/jm970197e. J Med Chem. 1997. PMID: 9371247

2

1,2-Benzothiazine 1,1-dioxide alpha-ketoamide analogues as potent calpain I inhibitors.

Bihovsky R, Tao M, Mallamo JP, Wells GJ. Bihovsky R, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1035-8. doi: 10.1016/j.bmcl.2003.11.037. Bioorg Med Chem Lett. 2004. PMID: 15013018

3

Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.

Tao M, Park CH, Bihovsky R, Wells GJ, Husten J, Ator MA, Hudkins RL. Tao M, et al. Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. doi: 10.1016/j.bmcl.2005.10.099. Epub 2005 Nov 15. Bioorg Med Chem Lett. 2006. PMID: 16290935

4

Synthesis and structure-activity relationships of novel pyrrolocarbazole lactam analogs as potent and cell-permeable inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).

Wells GJ, Bihovsky R, Hudkins RL, Ator MA, Husten J. Wells GJ, et al. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1151-5. doi: 10.1016/j.bmcl.2005.11.086. Epub 2005 Dec 15. Bioorg Med Chem Lett. 2006. PMID: 16359865

5

Novel peptidyl phosphorus derivatives as inhibitors of human calpain I.

Tao M, Bihovsky R, Wells GJ, Mallamo JP. Tao M, et al. Among authors: wells gj. J Med Chem. 1998 Sep 24;41(20):3912-6. doi: 10.1021/jm980325e. J Med Chem. 1998. PMID: 9748367

6

1,2-Benzothiazine 1,1-dioxide P(2)-P(3) peptide mimetic aldehyde calpain I inhibitors.

Wells GJ, Tao M, Josef KA, Bihovsky R. Wells GJ, et al. J Med Chem. 2001 Oct 11;44(21):3488-503. doi: 10.1021/jm010178b. J Med Chem. 2001. PMID: 11585453

7

P2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I.

Chatterjee S, Dunn D, Tao M, Wells G, Gu ZQ, Bihovsky R, Ator MA, Siman R, Mallamo JP. Chatterjee S, et al. Among authors: wells g. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2371-4. doi: 10.1016/s0960-894x(99)00392-3. Bioorg Med Chem Lett. 1999. PMID: 10476871

8

Strategies to mitigate the bioactivation of 2-anilino-7-aryl-pyrrolo[2,1-f][1,2,4]triazines: identification of orally bioavailable, efficacious ALK inhibitors.

Mesaros EF, Thieu TV, Wells GJ, Zificsak CA, Wagner JC, Breslin HJ, Tripathy R, Diebold JL, McHugh RJ, Wohler AT, Quail MR, Wan W, Lu L, Huang Z, Albom MS, Angeles TS, Wells-Knecht KJ, Aimone LD, Cheng M, Ator MA, Ott GR, Dorsey BD. Mesaros EF, et al. J Med Chem. 2012 Jan 12;55(1):115-25. doi: 10.1021/jm2010767. Epub 2011 Dec 29. J Med Chem. 2012. PMID: 22141319

9

2,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazines: new variant of an old template and application to the discovery of anaplastic lymphoma kinase (ALK) inhibitors with in vivo antitumor activity.

Ott GR, Wells GJ, Thieu TV, Quail MR, Lisko JG, Mesaros EF, Gingrich DE, Ghose AK, Wan W, Lu L, Cheng M, Albom MS, Angeles TS, Huang Z, Aimone LD, Ator MA, Ruggeri BA, Dorsey BD. Ott GR, et al. Among authors: wells gj. J Med Chem. 2011 Sep 22;54(18):6328-41. doi: 10.1021/jm200758k. Epub 2011 Aug 22. J Med Chem. 2011. PMID: 21859094

10

2,7-Disubstituted-pyrrolotriazine kinase inhibitors with an unusually high degree of reactive metabolite formation.

Wells-Knecht KJ, Ott GR, Cheng M, Wells GJ, Breslin HJ, Gingrich DE, Weinberg L, Mesaros EF, Huang Z, Yazdanian M, Ator MA, Aimone LD, Zeigler K, Dorsey BD. Wells-Knecht KJ, et al. Chem Res Toxicol. 2011 Nov 21;24(11):1994-2003. doi: 10.1021/tx200304r. Epub 2011 Nov 4. Chem Res Toxicol. 2011. PMID: 22023349

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