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Page 1
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
Mills EL, Kelly B, Logan A, Costa ASH, Varma M, Bryant CE, Tourlomousis P, Däbritz JHM, Gottlieb E, Latorre I, Corr SC, McManus G, Ryan D, Jacobs HT, Szibor M, Xavier RJ, Braun T, Frezza C, Murphy MP, O'Neill LA. Mills EL, et al. Cell. 2016 Oct 6;167(2):457-470.e13. doi: 10.1016/j.cell.2016.08.064. Epub 2016 Sep 22. Cell. 2016. PMID: 27667687 Free PMC article.
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
Accumulation of succinate controls activation of adipose tissue thermogenesis.
Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. Mills EL, et al. Nature. 2018 Aug;560(7716):102-106. doi: 10.1038/s41586-018-0353-2. Epub 2018 Jul 18. Nature. 2018. PMID: 30022159 Free PMC article.
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET. Mills EL, et al. Cell Metab. 2022 Jan 4;34(1):140-157.e8. doi: 10.1016/j.cmet.2021.11.003. Epub 2021 Dec 2. Cell Metab. 2022. PMID: 34861155 Free PMC article.
Active RNA interference in mitochondria.
Gao K, Cheng M, Zuo X, Lin J, Hoogewijs K, Murphy MP, Fu XD, Zhang X. Gao K, et al. Cell Res. 2021 Feb;31(2):219-228. doi: 10.1038/s41422-020-00394-5. Epub 2020 Aug 17. Cell Res. 2021. PMID: 32807841 Free PMC article.
Tetra-arylborate lipophilic anions as targeting groups.
Gaddale Devanna KK , Gawel JM , Prime TA , Cvetko F , Benincá C , Caldwell ST , Negoda A , Harrison A , James AM , Pavlov EV , Murphy MP , Hartley RC . Gaddale Devanna KK , et al. Chem Commun (Camb). 2021 Mar 28;57(25):3147-3150. doi: 10.1039/d0cc07924c. Epub 2021 Feb 26. Chem Commun (Camb). 2021. PMID: 33634803 Free PMC article.
MitoNeoD: A Mitochondria-Targeted Superoxide Probe.
Shchepinova MM, Cairns AG, Prime TA, Logan A, James AM, Hall AR, Vidoni S, Arndt S, Caldwell ST, Prag HA, Pell VR, Krieg T, Mulvey JF, Yadav P, Cobley JN, Bright TP, Senn HM, Anderson RF, Murphy MP, Hartley RC. Shchepinova MM, et al. Cell Chem Biol. 2017 Oct 19;24(10):1285-1298.e12. doi: 10.1016/j.chembiol.2017.08.003. Epub 2017 Sep 7. Cell Chem Biol. 2017. PMID: 28890317 Free PMC article.
64 results