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2011 2
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2014 3
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Page 1
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.
Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. Kaneko H, et al. Nature. 2011 Mar 17;471(7338):325-30. doi: 10.1038/nature09830. Epub 2011 Feb 6. Nature. 2011. PMID: 21297615 Free PMC article.
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.
Fowler BJ, Gelfand BD, Kim Y, Kerur N, Tarallo V, Hirano Y, Amarnath S, Fowler DH, Radwan M, Young MT, Pittman K, Kubes P, Agarwal HK, Parang K, Hinton DR, Bastos-Carvalho A, Li S, Yasuma T, Mizutani T, Yasuma R, Wright C, Ambati J. Fowler BJ, et al. Science. 2014 Nov 21;346(6212):1000-3. doi: 10.1126/science.1261754. Science. 2014. PMID: 25414314 Free PMC article.
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME, Ambati J. Tarallo V, et al. Cell. 2012 May 11;149(4):847-59. doi: 10.1016/j.cell.2012.03.036. Epub 2012 Apr 26. Cell. 2012. PMID: 22541070 Free PMC article.
Exaggerated eye growth in IRBP-deficient mice in early development.
Wisard J, Faulkner A, Chrenek MA, Waxweiler T, Waxweiler W, Donmoyer C, Liou GI, Craft CM, Schmid GF, Boatright JH, Pardue MT, Nickerson JM. Wisard J, et al. Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5804-11. doi: 10.1167/iovs.10-7129. Invest Ophthalmol Vis Sci. 2011. PMID: 21642628 Free PMC article.
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler BJ, Ambati BK, Bogdanovich S, Chiodo VA, Hauswirth WW, Kugel JF, Goodrich JA, Ponicsan SL, Hinton DR, Kleinman ME, Baffi JZ, Gelfand BD, Ambati J. Dridi S, et al. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13781-6. doi: 10.1073/pnas.1206494109. Epub 2012 Aug 6. Proc Natl Acad Sci U S A. 2012. PMID: 22869729 Free PMC article.
IL-18 is not therapeutic for neovascular age-related macular degeneration.
Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, Núñez G, Ambati BK, Hinton DR, Ambati J. Hirano Y, et al. Nat Med. 2014 Dec;20(12):1372-5. doi: 10.1038/nm.3671. Nat Med. 2014. PMID: 25473914 Free PMC article. No abstract available.
DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.
Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J. Kim Y, et al. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16082-7. doi: 10.1073/pnas.1403814111. Epub 2014 Oct 27. Proc Natl Acad Sci U S A. 2014. PMID: 25349431 Free PMC article.