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RNA base editing therapy cures hearing loss induced by OTOF gene mutation.
Xue Y, Tao Y, Wang X, Wang X, Shu Y, Liu Y, Kang W, Chen S, Cheng Z, Yan B, Xie Y, Bi L, Jia H, Li J, Xiao Q, Chen L, Yao X, Shi L, Yang H, Wu H. Xue Y, et al. Among authors: li j. Mol Ther. 2023 Dec 6;31(12):3520-3530. doi: 10.1016/j.ymthe.2023.10.019. Epub 2023 Nov 2. Mol Ther. 2023. PMID: 37915172
An engineered xCas12i with high activity, high specificity, and broad PAM range.
Zhang H, Kong X, Xue M, Hu J, Wang Z, Wei Y, Wang H, Zhou J, Zhang W, Xu M, Shen X, Yin F, Ai Z, Huang G, Xia J, Song X, Li H, Yuan Y, Li J, Zhong N, Zhang M, Zhou Y, Yang H. Zhang H, et al. Among authors: li j, li h. Protein Cell. 2023 Jun 28;14(7):538-543. doi: 10.1093/procel/pwac052. Protein Cell. 2023. PMID: 37378659 Free PMC article. No abstract available.
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