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Page 1
Showing results for prazosin p
Search for Plavosin P instead (1 results)
Clinical pharmacokinetics of prazosin.
Jaillon P. Jaillon P. Clin Pharmacokinet. 1980 Jul-Aug;5(4):365-76. doi: 10.2165/00003088-198005040-00004. Clin Pharmacokinet. 1980. PMID: 6994981 Review.
Preliminary studies in humans indicate that pathways for biotransformation of prazosin are similar to those observed in the rat and dog. Only 6% of prazosin is excreted unchanged, mainly in the urine. ...In both cases, the plasma free fraction of prazosin is …
Preliminary studies in humans indicate that pathways for biotransformation of prazosin are similar to those observed in the rat and d …
Effect of prazosin on feline recurrent urethral obstruction.
Hanson KR, Rudloff E, Yuan L, Mochel JP, Linklater AK. Hanson KR, et al. J Feline Med Surg. 2021 Dec;23(12):1176-1182. doi: 10.1177/1098612X211001283. Epub 2021 Mar 22. J Feline Med Surg. 2021. PMID: 33749375
There was no significant difference in frequency of rUO in cats treated with prazosin vs placebo (P = 0.27). CONCLUSIONS AND RELEVANCE: Prazosin administered at 0.5 mg PO q12h did not decrease the rate of rUO in this population of obstructed male cats vs plac …
There was no significant difference in frequency of rUO in cats treated with prazosin vs placebo (P = 0.27). CONCLUSIONS AND R …
The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats.
Rasmussen DD, Alexander LL, Raskind MA, Froehlich JC. Rasmussen DD, et al. Alcohol Clin Exp Res. 2009 Feb;33(2):264-72. doi: 10.1111/j.1530-0277.2008.00829.x. Epub 2008 Nov 19. Alcohol Clin Exp Res. 2009. PMID: 19032582 Free PMC article.

RESULTS: Prazosin significantly reduced (p < 0.01) alcohol intake during the initial 2 daily administrations, and this reduction of alcohol intake was maintained for 5 consecutive days by daily prazosin treatment in the subsequent more prolonged trial (

…

RESULTS: Prazosin significantly reduced (p < 0.01) alcohol intake during the initial 2 daily administrations, and this redu

…
Advances in the design and synthesis of prazosin derivatives over the last ten years.
Desiniotis A, Kyprianou N. Desiniotis A, et al. Expert Opin Ther Targets. 2011 Dec;15(12):1405-18. doi: 10.1517/14728222.2011.641534. Epub 2011 Dec 13. Expert Opin Ther Targets. 2011. PMID: 22148952 Free PMC article. Review.
AREAS COVERED: Advances over the last decade in the design and optimization of Prazosin, Doxazosin and Terazosin quinazoline-based derivatives as alpha1-AR antagonists. ...
AREAS COVERED: Advances over the last decade in the design and optimization of Prazosin, Doxazosin and Terazosin quinazoline-based de …
Prazosin Reduces Alcohol Intake in an Animal Model of Alcohol Relapse.
Froehlich JC, Hausauer B, Fischer S, Wise B, Rasmussen DD. Froehlich JC, et al. Alcohol Clin Exp Res. 2015 Aug;39(8):1538-46. doi: 10.1111/acer.12789. Alcohol Clin Exp Res. 2015. PMID: 26207767 Free PMC article.
This study explores whether prazosin prevents alcohol "relapse" in P rats, as reflected by a reduced or abolished ADE. ...CONCLUSIONS: Prazosin decreases alcohol intake in P rats even in a situation that would be expected to increase alcohol drinking, …
This study explores whether prazosin prevents alcohol "relapse" in P rats, as reflected by a reduced or abolished ADE. ...CONC …
The cytotoxicity of the alpha1-adrenoceptor antagonist prazosin is linked to an endocytotic mechanism equivalent to transport-P.
Fuchs R, Stracke A, Ebner N, Zeller CW, Raninger AM, Schittmayer M, Kueznik T, Absenger-Novak M, Birner-Gruenberger R. Fuchs R, et al. Toxicology. 2015 Dec 2;338:17-29. doi: 10.1016/j.tox.2015.09.008. Epub 2015 Oct 9. Toxicology. 2015. PMID: 26449523 Free PMC article.
Since the alpha1-adrenergic antagonist prazosin (PRZ) was introduced into medicine as a treatment for hypertension and benign prostate hyperplasia, several studies have shown that PRZ induces apoptosis in various cell types and interferes with endocytotic trafficking. ...B …
Since the alpha1-adrenergic antagonist prazosin (PRZ) was introduced into medicine as a treatment for hypertension and benign prostat …
Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder.
Sinha R, Fogelman N, Wemm S, Angarita G, Seo D, Hermes G. Sinha R, et al. Addict Biol. 2022 Mar;27(2):e13116. doi: 10.1111/adb.13116. Epub 2021 Dec 2. Addict Biol. 2022. PMID: 34856641 Free PMC article. Clinical Trial.
In Study 2, 23 AUD patients entering a 12-week randomised controlled trial (RCT) of Prazosin, an alpha1 adrenergic antagonist that decreased withdrawal-related alcohol intake in laboratory animals, participated in two fMRI sessions at pretreatment and also at week 9-10 of …
In Study 2, 23 AUD patients entering a 12-week randomised controlled trial (RCT) of Prazosin, an alpha1 adrenergic antagonist that de …
Search for the pharmacophore in prazosin for Transport-P.
Zunszain PA, Federico C, Sechi M, Al-Damluji S, Ganellin CR. Zunszain PA, et al. Bioorg Med Chem. 2005 Jun 1;13(11):3681-9. doi: 10.1016/j.bmc.2005.03.030. Bioorg Med Chem. 2005. PMID: 15862997
Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter. ...
Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structu …
A randomized controlled clinical trial of prazosin for alcohol use disorder in active duty soldiers: Predictive effects of elevated cardiovascular parameters.
Raskind MA, Williams T, Holmes H, Hart K, Crews L, Poupore EL, Thomas RG, Darnell J, Daniels C, Goke K, Hendrickson R, Terry G, Mayer C, Simpson T, Saxon A, Rasmussen D, Peskind ER. Raskind MA, et al. Alcohol Clin Exp Res (Hoboken). 2023 Feb;47(2):348-360. doi: 10.1111/acer.14989. Epub 2023 Feb 21. Alcohol Clin Exp Res (Hoboken). 2023. PMID: 36809662 Clinical Trial.
In soldiers with elevated standing systolic blood pressure (n = 27), prazosin reduced SDUs per day (p = 0.04) and tended to reduce % days drinking (p = 0.056). Prazosin also reduced depressive symptoms and the incidence of emergent depressed mood more …
In soldiers with elevated standing systolic blood pressure (n = 27), prazosin reduced SDUs per day (p = 0.04) and tended to re …
Treatment of Post-Traumatic Stress Disorders with the Alpha-1 Adrenergic Antagonist Prazosin.
Simon PY, Rousseau PF. Simon PY, et al. Can J Psychiatry. 2017 Mar;62(3):186-198. doi: 10.1177/0706743716659275. Epub 2016 Jul 19. Can J Psychiatry. 2017. PMID: 27432823 Free PMC article. Review.
OBJECTIVE: The present review aims to assess the clinical efficacy and safety of the alpha-1-adrenergic antagonist prazosin as primary pharmacologic treatment for post-traumatic stress disorder (PTSD). ...To be considered for inclusion, studies had to test the efficacy of …
OBJECTIVE: The present review aims to assess the clinical efficacy and safety of the alpha-1-adrenergic antagonist prazosin as primar …
4,555 results