Drug-induced urolithiasis

C A Osborne; J P Lulich; J W Bartges; L K Ulrich; L A Koehler; K A Bird; L L Swanson; G W Austin; E L Prien Jr; K U Steinam

doi:10.1016/s0195-5616(99)50014-4

Drug-induced urolithiasis

Vet Clin North Am Small Anim Pract. 1999 Jan;29(1):251-66, xiv. doi: 10.1016/s0195-5616(99)50014-4.

Authors

C A Osborne¹, J P Lulich, J W Bartges, L K Ulrich, L A Koehler, K A Bird, L L Swanson, G W Austin, E L Prien Jr, K U Steinam

Affiliation

¹ Minnesota Urolith Center, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA.

PMID: 10028161
DOI: 10.1016/s0195-5616(99)50014-4

Abstract

Diagnostic and therapeutic drugs may enhance urolithiasis in one or a combination of ways, including: (1) alteration of urine pH in such fashion as to create an environment that increases the solubility of some lithogenic substances, (2) alteration of glomerular filtration rate, tubular reabsorption, and tubular secretion of drugs of endogenous substances so as to enhance promoters or impair inhibitors of urolithiasis, and (3) precipitation (e.g., drugs or their metabolites) to form a portion or all of a urolith.

Publication types

Review

MeSH terms

Allopurinol / adverse effects
Animals
Anti-Bacterial Agents / adverse effects
Anti-Infective Agents / adverse effects
Anticonvulsants / adverse effects
Cat Diseases / chemically induced*
Cats
Dog Diseases / chemically induced*
Dogs
Enzyme Inhibitors / adverse effects
Fluoroquinolones
Primidone / adverse effects
Sulfonamides / adverse effects
Tetracycline / adverse effects
Urinary Calculi / chemically induced
Urinary Calculi / veterinary*
Xanthine Oxidase / antagonists & inhibitors

Substances

Anti-Bacterial Agents
Anti-Infective Agents
Anticonvulsants
Enzyme Inhibitors
Fluoroquinolones
Sulfonamides
Primidone
Allopurinol
Xanthine Oxidase
Tetracycline